Mutations and expression profile of EDIL3 and correlation with HIF1A and tumor-associated carbonic anhydrases in pancreatic cancer

Autor:	Dilara Fatma Akin, Rahsan Ilikci
Rok vydání:	2021
Předmět:	Correlation HIF1A EDIL3 HIF1A mutation expression Health Care Sciences and Services Pancreatic cancer Mutation (genetic algorithm) medicine Cancer research General Medicine Sağlık Bilimleri ve Hizmetleri Biology medicine.disease
Zdroj:	Volume: 11, Issue: 3 418-425 Clinical and Experimental Health Sciences
ISSN:	2459-1459
DOI:	10.33808/clinexphealthsci.756701
Popis:	Objective: EDIL3 expression levels are raised in some types of cancer which means that it can be used as a candidate tumor marker. Hypoxia upregulates tumor-associated carbonic anhydrases in cancer genesis. In this study, we aimed to investigate whether EDIL3 plays a role in the hypoxic microenvironment of pancreatic cancer. Methods: Gene expression and mutation profiles of pancreatic cancer patients and healthy tissue samples were downloaded The Cancer Genome Atlas (TCGA), and the genetic alterations and expression levels of the EDIL3, HIF1A, CA IX and CA XII genes were analyzed. Additionally, PolyPhen-2 and SNAP tools were used to prediction and confirmation of detected alterations pathogenicity and survival analysis was performed. Results: Expression level of EDIL3, HIF1A and CA IX were found to be statistically significant higher in the patient compared to healthy group and we showed also positive correlation between EDIL3 and HIF1A gene expression. Furthermore, low CA IX and CA XII expression level were found effective on overall survival (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8e3c0e70d2eaa370e9700b895121a7 https://doi.org/10.33808/clinexphealthsci.756701 Zobrazit plný text záznamu