ENUMERATION OF LEU2a±us;, LEU2a+-DR+, AND LEU2a+-LEU15+ CELLS IN PERIPHERAL BLOOD OF RENAL TRANSPLANT PATIENTS
| Autor: | A M, Kootte, F C, Henny, H J, Tanke, J, Slats, L A, van Es, L C, Paul |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Antigens Differentiation T-Lymphocyte Graft Rejection Male medicine.medical_specialty Lymphocyte Population Activation markers Cyclosporins T-Lymphocytes Regulatory Graft function Gastroenterology Leukocyte Count Postoperative Complications Internal medicine Humans Medicine Postoperative Period education Transplantation Kidney education.field_of_study business.industry HLA-DR Antigens Middle Aged Kidney Transplantation Peripheral blood medicine.anatomical_structure Renal transplant Cytomegalovirus Infections Immunology Leukocytes Mononuclear Female Disease Susceptibility business |
| Zdroj: | Transplantation. 45:132-137 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/00007890-198801000-00029 |
| Popis: | Immunological monitoring of peripheral blood cells of renal transplant patients may be helpful for diagnostic and prognostic purposes. We therefore enumerated the percentage of Leu2a+ cells as well as the occurrence of HLA-DR activation markers within this population. Since Leu2a+Leu15+ lymphocytes display suppressor functions in-vitro, this population was included in the study. Blood samples of 50 renal transplant patients within 3 months of transplantation and 41 pretransplant samples were investigated. As controls, peripheral blood cells from 10 healthy volunteers and 20 renal transplant patients with stable graft function more than 6 months after transplantation were examined. Just prior to transplantation the percentages of Leu2a+ cells, as well as the percentages of Leu15+ and DR+ cells within this population, varied considerably. Shortly after transplantation, clinical rejection episodes and cytomegalovirus (CMV) infections correlated with decreased percentages of Leu2a+ cells (P = 0.024 and 0.016, respectively). In nine patients with a decreased percentage of Leu2a+ cells shortly after transplantation but no rejection, the percentage of Leu2a+ cells normalized within 14 days. No correlation was found between increased percentages of Leu15+ or DR+ cells and rejection episodes, although the percentages of Leu2a+Leu15+ and Leu2a+DR+ cells increased significantly shortly before rejection (P less than 0.005). A decreased percentage of Leu2a+ cells, together with increased percentages of Leu15+ and DR+ cells, was seen in association with CMV infections (P less than 0.005). From this study we conclude that low percentages of Leu2a+ cells correlate with rejection episodes or CMV infections, whereas low percentages together with increased percentages of Leu2a+DR+ and Leu2a+Leu15+ cells are associated with CMV infections, especially in patients treated with high doses of cyclosporine. |
| Databáze: | OpenAIRE |
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