Clinical and pathologic features of patients with non-epithelial ovarian cancer: retrospective analysis of a single institution 15-year experience
Autor: | G. Desamericq, I. Diaz-Padilla, P. Estevez, B. Vieites, A. Garcia-Arreza, Ignacio Duran, E. Calvo, E. Kempf, M.A. Martinez-Maestre |
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Rok vydání: | 2016 |
Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty Prognostic factors 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Retrospective analysis Humans Epithelial ovarian cancer In patient Neoplasm Invasiveness Stage (cooking) Single institution Pathological Germ-cell tumors Neoplasm Staging Retrospective Studies Ovarian Neoplasms 030219 obstetrics & reproductive medicine business.industry General Medicine Middle Aged Neoplasms Germ Cell and Embryonal medicine.disease Prognosis Combined Modality Therapy Surgery Survival Rate 030220 oncology & carcinogenesis Sex-cord stromal tumors Lymphatic Metastasis Cohort Female Germ cell tumors Neoplasm Recurrence Local business Non-epithelial ovarian cancer Follow-Up Studies |
Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
ISSN: | 1699-3055 |
Popis: | [Purpose] Non-epithelial ovarian cancers (NEOCs) are rare diseases. Despite their overall good prognosis, the best management and current prognostic factors remain unclear. The objective of our study was to assess the clinical and pathological features of NEOC patients treated in our institution in the last 15 years and to explore risk factors for relapse and survival. [Methods/patients] All patients with a pathological diagnosis of NEOC referred to the medical oncology department at Hospital Universitario Virgen del Rocio between 1999 and 2014 were included. Demographics, tumor characteristics, treatment procedures, and clinical follow-up were retrospectively collected. Risk factors for disease-free survival (DFS) and overall survival (OS) were assessed. [Results] Fifty-seven patients were included, 33 (58 %) had a sex cord-stromal tumor (SCST) and 24 (42 %) had a germ-cell tumor (GCT). Median age, non-conservative surgery rates and DFS were lower in the GCT cohort; however, salvage chemotherapy led to a high proportion of complete responses in this group translating into a 90 % 3-year OS rate in both NEOC subtypes. The only identified risk factors statistically significant were stage and tumour relapse that associated, respectively, with DFS (HR = 8.84; 95 % CI 1.85–42) and OS (HR = 11.02; 95 % CI 1.76–68.7). [Conclusions] Despite their rarity, NEOCs remain a highly curable group of neoplasm. In our series, a more conservative treatment approach in ovarian GCTs revealed comparable OS outcomes to SCST. No new risk factors that would help in patient stratification were identified. |
Databáze: | OpenAIRE |
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