Effect of raloxifene on serum triglycerides in women with a history of hypertriglyceridemia while on oral estrogen therapy
| Autor: | Molly C. Carr, Pamela W. Anderson, John D. Brunzell, Xiaodong Zhu, Barbara S. Wheeler, Amy S. Rosen, Mark Lakshmanan, Robert H. Knopp |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Selective Estrogen Receptor Modulators
medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment Lipoproteins Estrogen receptor chemistry.chemical_compound Internal medicine Diabetes mellitus Internal Medicine medicine Humans Raloxifene Triglycerides Aged Advanced and Specialized Nursing Hypertriglyceridemia Triglyceride business.industry Estrogen Replacement Therapy Middle Aged medicine.disease Postmenopause Endocrinology Apolipoproteins Cholesterol chemistry Selective estrogen receptor modulator Estrogen Raloxifene Hydrochloride Patient Compliance Female Hormone therapy business medicine.drug |
| Zdroj: | Diabetes care. 28(7) |
| ISSN: | 0149-5992 |
| Popis: | OBJECTIVE—Raloxifene hydrochloride is a selective estrogen receptor modulator that to date has not been shown to cause hypertriglyceridemia in normal, diabetic, or hypertriglyceridemic women. This study was designed to assess the effect of raloxifene on serum triglycerides in postmenopausal women who have a history of increased hypertriglyceridemia with oral estrogen therapy. RESEARCH DESIGN AND METHODS—This was a single-center, uncontrolled, open-label study investigating the effects of 8 weeks of raloxifene (60 mg/day) therapy on plasma lipids. The study subjects were 12 postmenopausal women, ages 49–73 years, with a documented history of oral estrogen–induced hypertriglyceridemia (serum triglycerides ≥3.39 mmol/l [≥300 mg/dl]). RESULTS—At week 2 of the study, three (25%) of the subjects withdrew from the trial because they developed marked hypertriglyceridemia (≥11.3 mmol/l [≥1,000 mg/dl]) during raloxifene therapy. These three women had higher baseline triglyceride and glucose levels, were not being treated with lipid-lowering agents, and were more likely to have diabetes than the other study subjects. The remaining nine patients (75%) completed the 8-week trial and experienced a nonsignificant increase in mean triglyceride levels from baseline to end point. Raloxifene treatment also resulted in a significant 16% decrease in hepatic lipase activity and a 26% increase in HDL2 levels (P = 0.013 and 0.03, respectively). CONCLUSIONS—Patients with a previous history of hypertriglyceridemia on oral estrogen therapy should have serum triglyceride levels monitored closely after beginning raloxifene therapy and may even require fibrate therapy before beginning raloxifene. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|