Neuregulin 1 ICE-single nucleotide polymorphism in first episode schizophrenia correlates with cerebral activation in fronto-temporal areas
| Autor: | Ingo Frommann, Alexander Rapp, Dieter F. Braus, Martina von Wilmsdorf, Andrea Schmitt, Renate Thienel, Wolfgang Maier, Sibylle G. Schwab, Michael Wagner, Thilo Kellermann, N. Jon Shah, Wolfgang Gaebel, Frank Schneider, Wolfgang Wölwer, Fritz A. Henn, Tony Stöcker, Martina Reske, Tilo Kircher, Heinrich Sauer, Ute Habel |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Neuregulin-1 Precuneus Single-nucleotide polymorphism behavioral disciplines and activities Gyrus Cinguli Hippocampus Polymorphism Single Nucleotide Functional Laterality Young Adult Cerebellum mental disorders Genetic variation medicine Image Processing Computer-Assisted Humans Pharmacology (medical) Genetic Predisposition to Disease Allele Neuregulin 1 Biological Psychiatry Cerebral Cortex biology Working memory General Medicine medicine.disease Magnetic Resonance Imaging Temporal Lobe Frontal Lobe Psychiatry and Mental health medicine.anatomical_structure Haplotypes Schizophrenia biology.protein Neuregulin Female Psychology Neuroscience |
| Zdroj: | European archives of psychiatry and clinical neuroscience. 259(2) |
| ISSN: | 1433-8491 |
| Popis: | The Neuregulin (NRG1) gene has been associated with schizophrenia, but its functional implications are largely unknown. Our aim was to assess differential brain activation between patients carrying an at-risk allele on the Neuregulin 1 gene and patients without this genetic risk. Neural signal changes between 14 first episode schizophrenia patients with the at risk allele (SNP8NRG221533) from the Icelandic core haplotype and 14 without were measured with fMRI during a working memory task. Patients without the at risk allele showed greater activations (P < 0.05; corrected) in the left hippocampus, precuneus and cerebellum, as well as the right anterior cingulate. Brain regions previously associated with the pathology of Schizophrenia are differentially affected in those with a genetic at risk status in the NRG1 gene. Heterogeneity of structural and functional measures within patients characterized by clinical phenotypes may be in part due to this genetic variation. |
| Databáze: | OpenAIRE |
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