Cross-Sectional and Longitudinal Examination of Insulin Sensitivity and Secretion across Puberty among Non-Hispanic Black and White Children
| Autor: | Susan Z. Yanovski, Shannon E. Marwitz, Megan V Gaines, Miranda M. Broadney, Jack A. Yanovski, Sarah J. Mi, Van S. Hubbard, Sheila M. Brady |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty puberty insulin secretion Endocrinology Diabetes and Metabolism medicine.medical_treatment Black People 030209 endocrinology & metabolism Convenience sample lcsh:Diseases of the endocrine glands. Clinical endocrinology White People Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Insulin-Secreting Cells Internal medicine insulin resistance medicine Humans Insulin Longitudinal Studies Insulin secretion child lcsh:RC648-665 business.industry glucose clamp techniques Insulin sensitivity Overweight medicine.disease United States Cross-Sectional Studies 030220 oncology & carcinogenesis adolescent Clinical Study Female Original Article business Early puberty |
| Zdroj: | Endocrinology and Metabolism, Vol 35, Iss 4, Pp 847-857 (2020) Endocrinology and Metabolism |
| ISSN: | 2093-5978 |
| Popis: | Background: Few studies using criterion measures of insulin sensitivity (SI) and insulin secretory capacity (ISC) have been conducted across puberty to adulthood. We examined how SI and ISC change from pre-puberty through adulthood.Methods: Hyperglycemic clamp studies were performed in a convenience sample of non-Hispanic Black (NHB) and White children evaluated at age 6 to 12 years and at approximately 5-year intervals into adulthood (maximum age 27 years). SI and ISC (first-phase and steady-state insulin secretion) were determined cross-sectionally in 133 unique participants across puberty and in adulthood. Additionally, longitudinal changes in SI and ISC were compared at two timepoints among three groups defined by changes in pubertal development: pre-pubertal at baseline and late-pubertal at follow-up (n=27), early-pubertal at baseline and late-pubertal at follow-up (n=27), and late-pubertal at baseline and adult at follow-up (n=24).Results: Cross-sectionally, SI was highest in pre-puberty and early puberty and lowest in mid-puberty (analysis of covariance [ANCOVA] P=0.001). Longitudinally, SI decreased from pre-puberty to late puberty (PPPP=0.003) and greater first-phase and steady-state ISC (P≤0.001), independent of pubertal development.Conclusion: This study confirms that SI decreases and ISC increases transiently during puberty and shows that these changes largely resolve in adulthood. |
| Databáze: | OpenAIRE |
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