Determinants of lipid goal achievement in patients on extended-release nicotinic acid/laropiprant in primary care clinical practice
| Autor: | Claudia Buffleben, Wilfried Dänschel, David Pittrow, Elisabeth Steinhagen-Thiessen, Steven Hildemann |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Multivariate analysis Indoles Hypercholesterolemia Coronary Disease Primary care Niacin chemistry.chemical_compound Sex Factors Internal medicine Diabetes mellitus medicine Diabetes Mellitus Humans Aged Hypolipidemic Agents business.industry Cholesterol Cholesterol HDL Age Factors Disease Management General Medicine Cholesterol LDL Stepwise regression Middle Aged medicine.disease Nicotinic agonist Endocrinology chemistry Observational study Female business Laropiprant |
| Zdroj: | Current medical research and opinion. 29(1) |
| ISSN: | 1473-4877 |
| Popis: | To establish determinants of lipid goal attainment in primary care patients, with particular focus on participation in a disease management programme (DMP) on diabetes mellitus (DM) and/or coronary heart disease (CHD), with real-world practical relevance.The present analysis was based on an observational study in 2359 patients with dyslipidaemia or hypercholesterolaemia that were treated with nicotinic acid 1000 mg/laropiprant 20 mg (Tredaptive) one or two tablets daily. Subgroups were formed by DMP participation (DMP vs. no DMP). A stepwise logistic regression model with backward selection of variables was applied to investigate factors influencing the probability of reaching lipid goals. Follow-up was 23 ± 7 weeks.Low density lipoprotein cholesterol (LDL-C)100 mg/dl was achieved by 30.8% in DMP versus 26.8% (no DMP), high density lipoprotein (HDL-C)40/50 mg/dl in 61.3% versus 66.1%, and triglycerides (TG)150 mg/dl in 28.9% versus 31.7%. On multivariate analysis, age, sex, concomitant high-risk cardiovascular disease, or participation in a DMP appeared to have inconsistent effects on reaching LDL-C, HDL-C and TG goals. Likelihood to reach the LDL-C goal tended to be higher in males, in patients outside DMP, and in patients with DM or CHD, and those treated with 1 tablet (versus 2 tablets) extended release nicotinic acid 1000 mg/laropiprant 20 mg. The likelihood of reaching the HDL-C goal was higher in males and in patients without DM or DM+CHD (no effect of DMP). The likelihood of reaching the TG goals was higher in females, in patients outside DMP, and in patients with DM and/or CHD. Limitations include potential bias due to study design, physician and patient selection, and missing values at follow-up.DMP participation was not associated with overall improved lipid goal attainment. Physicians cannot predict the magnitude of effects of newly initiated lipid modifying therapy based on baseline characteristics of their patients. |
| Databáze: | OpenAIRE |
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