Latest in Vitro and in Vivo Assay, Clinical Trials and Patents in Cancer Treatment using Curcumin: A Literature Review
| Autor: | Pablo J. Álvarez, Raúl Ortiz, Jose Prados, Laura Cabeza, Consolación Melguizo, Kevin Doello |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Cancer Research Curcumin Chemosensitizer Medicine (miscellaneous) Metastasis Patents as Topic 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems 0302 clinical medicine In vivo Cell Line Tumor Neoplasms Animals Humans Medicine Tumor microenvironment Nutrition and Dietetics Neovascularization Pathologic business.industry In vitro toxicology Cancer medicine.disease Antineoplastic Agents Phytogenic Clinical trial 030104 developmental biology Oncology chemistry 030220 oncology & carcinogenesis Cancer research Female Drug Screening Assays Antitumor business |
| Zdroj: | Nutrition and Cancer. 70:569-578 |
| ISSN: | 1532-7914 0163-5581 |
| Popis: | Curcumin, the main active compound of the curcuma root, shows antioxidant, anti-inflammatory, and antitumor properties which have been demonstrated in preclinical and clinical trials. Its antitumor activity is mediated by its ability to act directly on the tumor cell, activating apoptosis pathways and indirectly inhibiting the process of inflammation, angiogenesis, and metastasis in the tumor microenvironment. In addition, it has a preventive activity such as radio and/or chemosensitizer. These effects have been evident in in vitro assays but have also been corroborated in patient trials either through the isolated use of curcumin or through its association with other agents. Moreover, curcumin has demonstrated a low induction of side effects. Numerous patents have been developed in connection with the administration and use of curcumin against different types of cancer. All this justifies the interest for the development of new laboratory studies and especially of clinical trials to validate this compound as a dietary supplement in both the healthy and the oncological population. The present review aims to address the most recent in vitro investigations and the latest clinical trials and patents related to the curcumin agent to provide an up-to-date overview of the latest advances in relation to its antitumor effect. |
| Databáze: | OpenAIRE |
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