Combination treatment with comprehensive cryoablation and immunotherapy in metastatic hepatocellular cancer
| Autor: | Feng Mu, Jialiang Li, Jibing Chen, Jian-Sheng Zuo, Jianying Zeng, Chun-Yan Liu, Fei Yao, Lizhi Niu, Kecheng Xu, Li Li, Meng-Tian Liao |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Carcinoma Hepatocellular Time Factors Brief Article viruses medicine.medical_treatment Cryotherapy macromolecular substances Kaplan-Meier Estimate environment and public health Cryosurgery Immunotherapy Adoptive Combined treatment Internal medicine Medicine Humans Cells Cultured Aged Retrospective Studies Hepatocellular cancer business.industry Liver Neoplasms Gastroenterology Cryoablation General Medicine Immunotherapy Dendritic Cells Middle Aged Combined Modality Therapy diagnosis humanities Coculture Techniques Surgery Killer Cells Natural Treatment Outcome Cytokines Female business |
| Popis: | To retrospectively assess the effect of comprehensive cryosurgery (ablation of intra- and extra-hepatic tumors) plus dendritic cell-cytokine-induced killer cell immunotherapy in metastatic hepatocellular cancer.We divided 45 patients into cryo-immunotherapy (21 patients), cryotherapy (n = 12), immunotherapy (n = 5) and untreated (n = 7) groups. Overall survival (OS) after diagnosis of metastatic hepatocellular cancer was assessed after an 8-year follow-up.Median OS was higher following cryo-immunotherapy (32 mo) or cryotherapy (17.5 mo; P0.05) than in the untreated group (3 mo) and was higher in the cryo-immunotherapy group than in the cryotherapy group (P0.05). In the cryo-immunotherapy group, median OS was higher after multiple treatments (36.5 mo) than after a single treatment (21 mo; P0.05).Cryotherapy and, especially, cryo-immunotherapy significantly increased OS in metastatic hepatocellular cancer patients. Multiple cryo-immunotherapy was associated with a better prognosis than single cryo-immunotherapy. |
| Databáze: | OpenAIRE |
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