Effect of intramyocardial bone marrow cell injection on left ventricular dyssynchrony and global strain
| Autor: | E R Holman, S A Mollema, J. van Ramshorst, D E Atsma, E. E. van der Wall, M.J. Schalij, J.J. Bax, N Ajmone Marsan, S L M A Beeres |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Myocardial Infarction Infarction Strain (injury) Ventricular Dysfunction Left Internal medicine medicine Humans Ventricular dyssynchrony Aged Bone Marrow Transplantation Heart Failure Tomography Emission-Computed Single-Photon Ejection fraction business.industry Stroke Volume Middle Aged medicine.disease medicine.anatomical_structure Echocardiography Heart failure Circulatory system Cardiology Leukocytes Mononuclear Myocardial infarction complications Female Bone marrow Cardiology and Cardiovascular Medicine business Epidemiologic Methods |
| Zdroj: | Heart (British Cardiac Society). 95(2) |
| ISSN: | 1468-201X |
| Popis: | To evaluate the effect of bone marrow cell injection on global strain and left ventricular (LV) dyssynchrony.In 14 patients with severe postinfarction heart failure, 93 (14) x 10(6) autologous bone marrow cells were percutaneously injected in the infarction border zone. LV ejection fraction (LVEF), LV dyssynchrony and echocardiographic global strain were assessed at baseline and 3 months in patients and in a non-randomised control group of 10 patients with a history of infarction who developed heart failure and were treated medically.No periprocedural complications occurred during bone marrow cell injection. At 3 months mean (SD) LVEF increased from 23 (8)% to 27 (9)% (p = 0.02) and global strain improved from -7.7 (4.7)% to -8.5 (4.9)% (p = 0.04). In patients withor =5% improvement in LVEF after bone marrow cell injection, global strain improved from -8.7 (4.6)% to -10.6 (4.5)% (p0.01). Global strain remained unchanged in patients with5% improvement in LVEF (-6.6 (4.9)% vs -6.4 (4.5)%, p = NS). The relation between the increase in LVEF and improvement in global strain was significant (r = 0.84, p0.01). In patients withor =5% improvement in LVEF, LV dyssynchrony decreased from 173 (64) ms to 116 (64) ms (p = 0.01). In patients with5% improvement in LVEF, LV dyssynchrony remained unchanged (155 (67) ms vs 177 (81) ms, p = NS). The correlation between improvement in LVEF and reduction in LV dyssynchrony was good (r = -0.77, p0.01). In the control group, LVEF, global strain and LV dyssynchrony did not improve.Bone marrow cell injection improves LVEF in patients with severe postinfarction heart failure. The improvement in LVEF was related to reduced LV dyssynchrony and increased global strain. |
| Databáze: | OpenAIRE |
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