Recognition memory and verbal fluency differentiate probable Alzheimer disease from subcortical ischemic vascular dementia
| Autor: | G. Nadon, R. H. Fisher, Helena C. Chui, W. G. Snow, John P. Szalai, Sandra E. Black, Mary C. Tierney |
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| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Logic Trail Making Test Word Association Tests Audiology Neuropsychological Tests Developmental psychology Diagnosis Differential Mental Processes Arts and Humanities (miscellaneous) Alzheimer Disease Memory medicine Verbal fluency test Dementia Humans Vascular dementia Aged Aged 80 and over Likelihood Functions Informed Consent medicine.diagnostic_test Dementia Vascular Controlled Oral Word Association Test Recognition Psychology Neuropsychological test medicine.disease Educational Status Perception Neurology (clinical) Alzheimer's disease Verbal memory Psychology Mental Status Schedule |
| Zdroj: | Archives of neurology. 58(10) |
| ISSN: | 0003-9942 |
| Popis: | Background Alzheimer disease (AD) and vascular dementia are among the most frequently occurring causes of dementia in the world, and their accurate differentiation is important because different pharmaceutical strategies may modify the course of each disease. Objective To determine which of 10 neuropsychological test scores can accurately differentiate patients with probable AD from those with subcortical ischemic vascular dementia (SIVD) for use in evidence-based clinical practice. Design Patients with suspected dementia were referred to the study by family physicians, geriatricians, and neurologists. All participants received a thorough assessment according to standard diagnostic guidelines. Diagnoses of probable AD (n = 31) and probable SIVD (n = 31) were made according to consensus criteria. The diagnosticians were blind to the results of the 10 neuropsychological test scores. Results There were no significant differences between the groups in age or Mini-Mental State Examination scores. Logistic regression analyses identified 2 neuropsychological tests that best distinguished the groups (sensitivity = 81%; specificity = 84%; positive likelihood ratio = 5.1). These were the recognition memory subtest of the Rey Auditory Verbal Learning Test and the Controlled Oral Word Association Test. The AD group performed better on the oral association test, whereas the SIVD group did better on the recognition memory test. Conclusion Patients with probable AD and probable SIVD can be distinguished with a high degree of accuracy using these 2 neuropsychological tests. |
| Databáze: | OpenAIRE |
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