Primary Large Cell Neuroendocrine Carcinoma of the Parotid Gland. Report of a Rare Case
| Autor: | Dimitrios Vlachodimitropoulos, Vasileios Papanikolaou, Nikolaos Goutas, Konstantinos I. Tosios |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Case Reports Neuroendocrine differentiation Pathology and Forensic Medicine Metastasis Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Major Salivary Gland Biomarkers Tumor medicine Carcinoma Humans Neoplasm Staging Aged 80 and over biology business.industry Large cell medicine.disease Combined Modality Therapy Carcinoma Neuroendocrine Parotid Neoplasms Parotid gland 030104 developmental biology medicine.anatomical_structure Oncology Otorhinolaryngology Salivary Gland Diseases 030220 oncology & carcinogenesis Synaptophysin biology.protein Carcinoma Large Cell Neoplasm Grading Tomography X-Ray Computed business |
| Zdroj: | Head Neck Pathol |
| ISSN: | 1936-0568 |
| DOI: | 10.1007/s12105-021-01300-0 |
| Popis: | Primary neuroendocrine carcinomas of the salivary glands are very rare neoplasms that present light microscopic, ultrastructural, and immunohistochemical features of neuroendocrine differentiation. Twelve cases have been published in the English language literature. We describe the pathologic features of a case of primary large cell neuroendocrine carcinoma of the parotid gland in a 91-year old male and summarize the immunophenotype of previously reported LCNECs of the major salivary glands. It is concluded that primary LCNEC of the salivary glands presents as a high-grade undifferentiated carcinoma, whose diagnosis may be hindered by its rarity and non-specific light microscopic features. A high level of awareness, immunohistochemical staining for neuroendocrine markers synaptophysin and CD56, and a thorough diagnostic work-up in order to exclude metastasis from a primary neuroendocrine carcinoma will allow its diagnosis. |
| Databáze: | OpenAIRE |
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