In vivo validation of compensatory enlargement of atherosclerotic coronary arteries
| Autor: | Harry R. Phillips, Charles J. Davidson, Katherine B. Kisslo, Alan N. Tenaglia, Richard S. Stack, James B. Hermiller, Thomas M. Bashore |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Lumen (anatomy) Coronary Artery Disease Internal medicine Intravascular ultrasound medicine Humans Aged Ultrasonography medicine.diagnostic_test business.industry Vascular disease Ultrasound Blood flow Middle Aged Internal elastic lamina medicine.disease Adaptation Physiological Coronary Vessels Coronary arteries Stenosis medicine.anatomical_structure Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | The American Journal of Cardiology. 71:665-668 |
| ISSN: | 0002-9149 |
| Popis: | Necropsy examinations and epicardial ultrasound studies have suggested that atherosclerotic coronary arteries undergo compensatory enlargement. This increase in vessel size may be an important mechanism for maintaining myocardial blood flow. It also is of fundamental importance in the angiographic study of coronary disease progression and regression. The purpose of this study was to determine, using intracoronary ultrasound, whether coronary arteries undergo adaptive expansion in vivo. Forty-four consecutive patients were studied (30 men, 14 women; mean age 56 ± 10 years). Eighty intravascular ultrasound images were analyzed (32 left main, 23 left anterior descending and 25 right coronary arteries). Internal elastic lamina area, a measure of overall vessel size increased as plaque area expanded (r = 0.57, p = 0.0001, SEE = 5.5 mm2). When the left main, left anterior descending and right coronary arteries were examined individually, there continued to be as great or greater positive correlation between internal elastic lamina and plaque area (left anterior descending: r = 0.75, p = 0.0001; right coronary arteries: r = 0.63, p = 0.0007; left main: r = 0.56, p = 0.0009), implying that each of the vessels and all in aggregate underwent adaptive enlargement. When only those vessels with |
| Databáze: | OpenAIRE |
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