Multiple lineages of Streptomyces produce antimicrobials within passalid beetle galleries across eastern North America
| Autor: | Matthew F. Traxler, Laila El-Hifnawi, Jewel N Reaso, Eoin L. Brodie, Rita de Cassia Pessotti, Javier A. Ceja-Navarro, Bridget L. Hansen |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Range (biology) QH301-705.5 natural products media_common.quotation_subject Science infectious disease 030106 microbiology Zoology Metarhizium anisopliae Insect Streptomyces General Biochemistry Genetics and Molecular Biology bessbug 03 medical and health sciences Feces Symbiosis Anti-Infective Agents actinomycetes Animals 2.2 Factors relating to the physical environment Aetiology Biology (General) Phylogeny media_common General Immunology and Microbiology biology General Neuroscience Frass microbiology Fungi chemical ecology General Medicine biology.organism_classification odontotaenius disjunctus symbiosis Chemical ecology Odontotaenius disjunctus Coleoptera 030104 developmental biology Infectious Diseases North America Medicine Biochemistry and Cell Biology ecology |
| Zdroj: | eLife, Vol 10 (2021) |
| Popis: | Some insects form symbioses in which actinomycetes provide defense against pathogens by making antimicrobials. The range of chemical strategies employed across these associations, and how these strategies relate to insect lifestyle, remains underexplored. We assessed subsocial passalid beetles of the species Odontotaenius disjunctus, and their frass (fecal material), which is an important food resource within their galleries, as a model insect/actinomycete system. Through chemical and phylogenetic analyses, we found that O. disjunctus frass collected across eastern North America harbored multiple lineages of Streptomyces and diverse antimicrobials. Metabolites detected in frass displayed synergistic and antagonistic inhibition of a fungal entomopathogen, Metarhizium anisopliae, and multiple streptomycete isolates inhibited this pathogen when co-cultivated directly in frass. These findings support a model in which the lifestyle of O. disjunctus accommodates multiple Streptomyces lineages in their frass, resulting in a rich repertoire of antimicrobials that likely insulates their galleries against pathogenic invasion. |
| Databáze: | OpenAIRE |
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