Susceptibility in vitro of clinically metronidazole-resistant Trichomonas vaginalis to nitazoxanide, toyocamycin, and 2-fluoro-2'-deoxyadenosine
| Autor: | Anita Burgess, Linda A. Dunn, Kenia G. Krauer, Zygmunt Kazimierczuk, Jacqueline A. Upcroft, Peter Upcroft, Janelle M. Wright |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Drug Resistance
Antitrichomonal Agents Drug resistance Microbial Sensitivity Tests Biology medicine.disease_cause Microbiology Minimum inhibitory concentration chemistry.chemical_compound Deoxyadenosine Metronidazole medicine Trichomonas vaginalis Humans Anaerobiosis Cross-resistance Toyocamycin General Veterinary Deoxyadenosines Nitazoxanide General Medicine Nitro Compounds Tinidazole Thiazoles Infectious Diseases chemistry Insect Science Parasitology Female Trichomonas Vaginitis medicine.drug |
| Zdroj: | Parasitology research. 107(4) |
| ISSN: | 1432-1955 |
| Popis: | This study investigates the susceptibility of a clinically metronidazole (Mz)-resistant isolate of Trichomonas vaginalis to alternative anti-trichomonal compounds. The microaerobic minimal inhibitory concentration (MIC) of the 5-nitroimidazole (NI) drug, Mz, against a typical Mz-susceptible isolate of T. vaginalis is around 3.2 microM Mz while the clinically, highly Mz-resistant isolate has an MIC of 50-100 microM. This isolate was cross-resistant to other members of the 5-NI family of compounds including tinidazole and other experimental compounds and maintained resistance under anaerobic conditions. In addition, this isolate was cross-resistant to the 5-nitrothiazole compound nitazoxanide and the 5-nitrofuran derivative, furazolidone. Adenosine analogues toyocamycin and 2-fluoro-2'-deoxyadenosine with no nitro group were also less effective against the clinically Mz-resistant isolate than a Mz-susceptible one. Three other isolates which were determined to be Mz-resistant soon after isolation lost resistance in the long term. One other isolate has maintained some level of permanent Mz resistance (MIC of 25 microM). A multi-drug resistance mechanism may be involved in these clinically Mz-resistant isolates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink