Acute promyelocytic leukemia: Cytogenetics and bone-marrow culture
| Autor: | Clark, Jan Fraser, D. C. Heaton, Peter E. Hollings, Day Wa, Peter H. Fitzgerald, M. E. J. Beard, J. W. Hamer |
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| Rok vydání: | 1981 |
| Předmět: |
Male
Acute promyelocytic leukemia Cancer Research medicine.medical_specialty Pathology Myeloid Chromosomal translocation Biology Translocation Genetic Bone Marrow medicine Humans Child Aged Chromosomes Human 16-18 Acute leukemia Blood Cells Cell growth Cytogenetics Karyotype Middle Aged medicine.disease Chromosome Banding Culture Media Leukemia Myeloid Acute Microscopy Electron Leukemia medicine.anatomical_structure Oncology Female Chromosomes Human 13-15 New Zealand |
| Zdroj: | International Journal of Cancer. 27:167-173 |
| ISSN: | 1097-0215 0020-7136 |
| DOI: | 10.1002/ijc.2910270207 |
| Popis: | Six patients were diagnosed as having acute promyelocytic leukemia (APL) according to FAB criteria. One patient conformed to the M3 variant. Informative cytogenetic results (G-banding) on five of the patients showed that three of them, including the M3 variant, had the 15;17 translocation in bone-marrow or blood cells. Cells with the translocation were accompanied by cells with a normal karyotype in all patients and no other chromosomal abnormality was present. This first report of the 15;17 translocation from the South Pacific region is relevant to the uneven geographical distribution of APL patients with the translocation. Five of the six patients including the M3 variant, showed a distinctive pattern of cell growth in agar culture characterized by a profusion of small, uniform clusters containing 6-20 cells with the appearance of promyelocytes. The remaining patient had a pattern of cell growth more typical of M2 acute leukemia. This cell growth pattern may be useful in diagnosing and monitoring the course of APL. |
| Databáze: | OpenAIRE |
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