Iron deposition in periaqueductal gray matter as a potential biomarker for chronic migraine
| Autor: | Francisco Campos, Ana Jeremías López, Clara Domínguez, Carmen Villalba, Alba Vieites-Prado, Pedro Ramos-Cabrer, Xiana Rodríguez-Osorio, María Pérez-Mato, José Castillo, Tomás Sobrino, Rogelio Leira |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Red nucleus Iron Migraine Disorders Globus Pallidus Sensitivity and Specificity Gastroenterology 03 medical and health sciences 0302 clinical medicine Chronic Migraine Internal medicine Image Processing Computer-Assisted medicine Humans Periaqueductal Gray Prospective Studies Endothelial dysfunction Red Nucleus medicine.diagnostic_test business.industry Case-control study Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Pathophysiology 030104 developmental biology Globus pallidus Migraine Case-Control Studies Chronic Disease Female Neurology (clinical) business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Neurology. 92:e1076-e1085 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.0000000000007047 |
| Popis: | ObjectiveTo study iron deposition in red nucleus (RN), globus pallidus (GP), and periaqueductal gray matter (PAG) as a potential biomarker of chronic migraine (CM) and its association with levels of biomarkers related to migraine pathophysiology.MethodsThis case-control study included 112 patients with migraine (55 CM, 57 episodic migraine [EM]) and 25 headache-free controls. We analyzed iron deposition using 3T MRI and the NIH software platform ImageJ; we analyzed serum levels of markers of inflammation, endothelial dysfunction, and blood-brain barrier (BBB) disruption by ELISA in peripheral blood during interictal periods.ResultsPatients with CM showed larger iron grounds volume in RN compared to patients with EM (70.2 ± 6.8 vs 25.5 ± 7.3 μL, p < 0.001) and controls (70.2 ± 6.8 vs 15.1 ± 10.8 μL, p < 0.001), as well as larger iron deposits in PAG compared to patients with EM (360.3 ± 6.5 vs 249.7 ± 6.9 μL, p < 0.001) and controls (360.3 ± 6.5 vs 168.6 ± 10.3 μL, p < 0.001). In PAG, differences were also significant between patients with EM and controls. No significant differences were obtained for GP. Receiver operating characteristic curves showed that the optimal threshold for iron volume was 15 μL in RN (80% sensitivity, 71% specificity) and 240 μL in PAG (93% sensitivity, 97% specificity). Iron grounds volume in PAG was correlated with higher plasma levels of soluble tumor necrosis factor–like WEAK (r = 0.395, p = 0.005) and cellular fibronectin (r = 0.294, p = 0.040).ConclusionsPatients with CM showed increased iron deposition in RN and PAG compared to patients with EM and controls. Iron grounds volume in PAG identified correctly patients with CM and was associated with elevated biomarkers of endothelial dysfunction and BBB disruption. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|