Adenosine Kinase Expression in the Frontal Cortex in Schizophrenia
| Autor: | Detlev Boison, Robert E. McCullumsmith, Ryan C Devore Homan, Cassidy Lynn Moody, Adam J. Funk, Sinead M. O’Donovan, Emily Devine |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adenosine Gene Expression Prefrontal Cortex Tissue Banks Adenosine kinase Gyrus Cinguli behavioral disciplines and activities Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Dopamine Internal medicine mental disorders medicine Animals Humans Adenosine Kinase Anterior cingulate cortex Aged 030304 developmental biology Aged 80 and over 0303 health sciences biology Glutamate receptor Hep G2 Cells Middle Aged medicine.disease Rats ADK Dorsolateral prefrontal cortex Psychiatry and Mental health Endocrinology medicine.anatomical_structure Schizophrenia biology.protein Female 030217 neurology & neurosurgery Antipsychotic Agents Regular Articles medicine.drug |
| Zdroj: | Schizophr Bull |
| ISSN: | 1745-1701 0586-7614 |
| DOI: | 10.1093/schbul/sbz086 |
| Popis: | The adenosine hypothesis of schizophrenia posits that reduced availability of the neuromodulator adenosine contributes to dysregulation of dopamine and glutamate transmission and the symptoms associated with schizophrenia. It has been proposed that increased expression of the enzyme adenosine kinase (ADK) may drive hypofunction of the adenosine system. While animal models of ADK overexpression support such a role for altered ADK, the expression of ADK in schizophrenia has yet to be examined. In this study, we assayed ADK gene and protein expression in frontocortical tissue from schizophrenia subjects. In the dorsolateral prefrontal cortex (DLPFC), ADK-long and -short splice variant expression was not significantly altered in schizophrenia compared to controls. There was also no significant difference in ADK splice variant expression in the frontal cortex of rats treated chronically with haloperidol-decanoate, in a study to identify the effect of antipsychotics on ADK gene expression. ADK protein expression was not significantly altered in the DLPFC or anterior cingulate cortex (ACC). There was no significant effect of antipsychotic medication on ADK protein expression in the DLPFC or ACC. Overall, our results suggest that increased ADK expression does not contribute to hypofunction of the adenosine system in schizophrenia and that alternative mechanisms are involved in dysregulation of this system in schizophrenia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|