| Autor: |
David G. Lott, Manisha Shah, Cheryl Myers, Michael McPhail, Juergen Neubauer, Jason Struthers, Cathy S. Madsen, Danielle Grandjean, Stephanie R. C. Zacharias, Yourka D. Tchoukalova |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
The LaryngoscopeREFERENCES. 132 |
| ISSN: |
1531-4995 |
| Popis: |
Develop a patient-specific tissue engineered construct for laryngeal reconstruction following a partial laryngectomy.Bench and animal research.A construct made from a porous polyethylene scaffold shaped in a canine-specific configuration and seeded with autologous canine adipose-derived stem cells in fibrin glue was implanted in a canine following a partial laryngectomy. After 1 year, the construct was first evaluated in vivo with high-speed imaging and acoustic-aerodynamic measures. It was then explanted and evaluated histologically.The canine study at 1 year revealed the construct provided voicing (barking) with acoustic and aerodynamic measures within normal ranges. The canine was able to eat and breathe normally without long-term support. The construct was integrated with epithelialization of all areas except the medial portion of the vocal fold structure. No anti-infective agents were needed after the standard perioperative medications were completed.This study provided a successful first step toward developing a patient-specific composite construct for patients undergoing partial laryngectomies.NA Laryngoscope, 132:S1-S11, 2022. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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