Efficacy of Combined Antithrombotic, Statins and Anti-Hypertensive Drugs in Acute Ischemic Stroke
| Autor: | Ramesh Sharma Poudel, Lekh Jung Thapa, Tritha Raj Bhandari, Shakti Shrestha, Nijan Upadhyay, Asis Shrestha, Dipendra Khatiwada |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty antihypertensive anti-thrombotic efficacy statins stroke Context (language use) Severity of Illness Index Brain Ischemia Hospitals University Brain ischemia Fibrinolytic Agents Nepal Risk Factors Modified Rankin Scale Internal medicine Severity of illness medicine Humans Prospective Studies cardiovascular diseases Prospective cohort study Stroke Antihypertensive Agents Aged Aged 80 and over lcsh:R5-920 business.industry General Medicine Middle Aged medicine.disease Survival Analysis Cross-Sectional Studies Treatment Outcome Blood pressure Physical therapy Drug Therapy Combination Female Hydroxymethylglutaryl-CoA Reductase Inhibitors business lcsh:Medicine (General) Fibrinolytic agent Follow-Up Studies |
| Zdroj: | Journal of Nepal Medical Association, Vol 53, Iss 197, Pp 5-11 (2015) Europe PubMed Central Journal of Nepal Medical Association, Vol 53, Iss 197 (2015) |
| ISSN: | 0028-2715 |
| Popis: | Introduction: Anti-thrombotic, statins and antihypertensive drugs are commonly used for the management of acute ischemic stroke in Nepal but there is no evidence regarding their efficacy in our context. This study aims to explore the efficacy of these combined medications (anti-thrombotic, statins and antihypertensive drugs) in acute ischemic stroke patients for the first time and to assess the risk factors present in those patients. Methods: The study was conducted on 37 acute ischemic stroke patients admitted and treated at the Neurology Department of College of Medical Sciences-Teaching Hospital, Chitwan, Nepal and they were followed at three months (90±10 days). The initial stroke severity and functional disability were evaluated at admission and at 3 months using National Institute of Health Stroke Scale (NIHSS) and Modified Rankin Scale (mRS) respectively. The outcome parameters were functional independence (mRS≤2) and mortality at three months (mRS=6). Frequency distribution, Mann-Whitney U-test and χ2 test were performed for statistical analysis. Results: Out of 37 patients, 27 (73%) were Smoker, 22 (59.5%) had hypertension and 19 (51.4%) were alcohol consumer. The stroke severity on admission was statistically significant with functional independence (P=0.003) and mortality (P=0.015) at three month. Similarly, Rankin grade on admission was statistically significant with functional independence (P=0.001) and mortality (P=0.048) at three month. At three months, 20 (69%) survived patients were independent while mortality was seen in eight (21.6%) patients. Conclusions: The management of acute ischemic stroke with combined anti-thrombotic, statins and antihypertensive drugs seems promising and efficacious in mild to moderately severe ischemic stroke. Keywords: antihypertensive; anti-thrombotic; efficacy ; statins; stroke. |
| Databáze: | OpenAIRE |
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