Rhythm disturbances as a potential early marker of Parkinson’s disease in idiopathic REM sleep behavior disorder

Autor: Christian Geny, Valérie Driss, Simone Dalla Bella, Pascale Homeyer, Chloé Gonzalvez, Bertrand Carlander, Benoît G. Bardy, Valérie Cochen De Cock, Florence Galtier, Loic Damm, Nicolas Pageot, Aurélie Giordano, C. Lebrun, Beatriz Abril, Marie Christine Picot, Delphine de Verbizier, Giovanni Castelnovo
Přispěvatelé: CIC Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-CHU Saint-Eloi-Institut National de la Santé et de la Recherche Médicale (INSERM), Euromov (EuroMov), Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
Parkinson's disease
media_common.quotation_subject
Neurosciences. Biological psychiatry. Neuropsychiatry
REM Sleep Behavior Disorder
Audiology
Motor Activity
REM sleep behavior disorder
03 medical and health sciences
Olfaction Disorders
0302 clinical medicine
Rhythm
Dopamine
Perception
medicine
Humans
RC346-429
Research Articles
media_common
Aged
Tomography
Emission-Computed
Single-Photon
Dopamine Plasma Membrane Transport Proteins
business.industry
General Neuroscience
Dysautonomia
Parkinson Disease
Middle Aged
medicine.disease
Tapping rate
030104 developmental biology
Finger tapping
Time Perception
Auditory Perception
Female
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Neurology (clinical)
Neurology. Diseases of the nervous system
medicine.symptom
Cues
business
030217 neurology & neurosurgery
Biomarkers
Psychomotor Performance
medicine.drug
Research Article
RC321-571
Zdroj: Annals of Clinical and Translational Neurology, Vol 7, Iss 3, Pp 280-287 (2020)
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology, Wiley, 2020, 7 (3), pp.280-287. ⟨10.1002/acn3.50982⟩
ISSN: 2328-9503
DOI: 10.1002/acn3.50982⟩
Popis: International audience; Objective: We aimed to identify timing distortions in production and perception of rhythmic events in patients with idiopathic REM sleep behavior disorder (iRBD) as early markers of Parkinson's disease (PD).Methods: Rhythmic skills, clinical characteristics, dysautonomia, depression, and olfaction were compared in 97 participants, including 21 participants with iRBD, 38 patients with PD, and 38 controls, matched for age, gender, and education level. Rhythmic disturbances can be easily detected with dedicated motor tasks via a tablet application. Rhythm production was tested in two conditions: to examine the ability to generate a spontaneous endogenous rhythm, tapping rate and variability in a finger tapping task without external stimulation was measured, while the ability to synchronize to an external rhythm was tested with finger tapping to external auditory cues. Rhythm perception was measured with a task, in which the participants had to detect a deviation from a regular rhythm. Participants with iRBD had dopamine transporter imaging.Results: Participants with iRBD and PD revealed impaired spontaneous rhythm production and poor rhythm perception compared to controls. Impaired rhythm production was correlated with olfaction deficits, dysautonomia, impaired non-motor aspects of daily living, and dopamine uptake measures.Conclusions: Participants with iRBD show impaired rhythm production and perception; this impairment is correlated with other early markers for PD. Testing rhythmic skills with short and inexpensive tests may be promising for screening for potential future PD in iRBD patients.
Databáze: OpenAIRE
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