Early prediction of putamen imaging features in HIV-associated neurocognitive impairment syndrome
| Autor: | Hai-Xia Ren, Wei Wang, Man Xu, Ruili Li, Qi Y, Ming-Ming Liu, Yuanyuan Wang, Jiaojiao Liu, Hongjun Li |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty AIDS Dementia Complex Neuropsychological Tests Asymptomatic lcsh:RC346-429 Correlation 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Verbal fluency test Humans Cognitive Dysfunction Neuropsychological assessment lcsh:Neurology. Diseases of the nervous system Retrospective Studies Radiomics medicine.diagnostic_test Receiver operating characteristic business.industry Putamen HIV Asymptomatic neurocognitive impairment Brain Cognition General Medicine Magnetic Resonance Imaging body regions 030104 developmental biology Cardiology Radiographic Image Interpretation Computer-Assisted Female Neurology (clinical) medicine.symptom business Neurocognitive 030217 neurology & neurosurgery Research Article |
| Zdroj: | BMC Neurology BMC Neurology, Vol 21, Iss 1, Pp 1-10 (2021) |
| ISSN: | 1471-2377 |
| Popis: | Background To explore the correlation between the volume of putamen and brain cognitive impairment in patients with HIV and to predict the feasibility of early-stage HIV brain cognitive impairment through radiomics. Method Retrospective selection of 90 patients with HIV infection, including 36 asymptomatic neurocognitive impairment (ANI) patients and 54 pre-clinical ANI patients in Beijing YouAn Hospital. All patients received comprehensive neuropsychological assessment and MRI scanning. 3D Slicer software was used to acquire volume of interest (VOI) and radiomics features. Clinical variables and volume of putamen were compared between patients with ANI and pre-clinical ANI. The Kruskal Wallis test was used to analysis multiple comparisons between groups. The relationship between cognitive scores and VOI was compared using linear regression. For radiomics, principal component analysis (PCA) was used to reduce model overfitting and calculations and then a support vector machine (SVM) was used to build a binary classification model. For model performance evaluation, we used an accuracy, sensitivity, specificity and receiver operating characteristic curve (ROC). Result There were no significant differences in clinical variables between ANI group and pre-clinical-ANI group (P>0.05). The volume of bilateral putamen was significantly different between AHI group and pre-clinical group (PP = 0.063). Reduced cognitive scores in Verbal Fluency, Attention/Working Memory, Executive Functioning, memory and Speed of Information Processing were negatively correlated with the increased VOI (P Conclusion The volumes of putamen in patients with ANI may be larger than patients with pre-clinical ANI, the change of the volume of the putamen may have a certain process; there is a relationship between putamen and cognitive impairment, but the exact mechanism is unclear. Radiomics may be a useful tool for predicting early stage HAND in patients with HIV. |
| Databáze: | OpenAIRE |
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