Faecal immunochemical test outside colorectal cancer screening?
| Autor: | Noel Pin-Vieito, Daniel Fernández-de-Castro, Manuel Puga, Joaquín Cubiella |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adenoma
medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Colorectal cancer Faecal biomarkers Colonoscopy Sensitivity and Specificity Feces Hemoglobins Health care Pandemic medicine Humans Mass Screening Faecal haemoglobin Intensive care medicine Mass screening Early Detection of Cancer medicine.diagnostic_test Faecal immunochemical test business.industry SARS-CoV-2 Gastroenterology COVID-19 Minireviews General Medicine medicine.disease digestive system diseases Test (assessment) Occult Blood Biomarker (medicine) Diagnostic performance business Colorectal Neoplasms Primary healthcare |
| Zdroj: | World Journal of Gastroenterology |
| ISSN: | 2219-2840 |
| Popis: | Faecal immunochemical tests (FITs) are the most widely colorectal cancer (CRC) diagnostic biomarker available. Many population screening programmes are based on this biomarker, with the goal of reducing CRC mortality. Moreover, in recent years, a large amount of evidence has been produced on the use of FIT to detect CRC in patients with abdominal symptoms in primary healthcare as well as in surveillance after adenoma resection. The aim of this review is to highlight the available evidence on these two topics. We will summarize the evidence on diagnostic yield in symptomatic patients with CRC and significant colonic lesion and the different options to use this (thresholds, brands, number of determinations, prediction models and combinations). We will include recommendations on FIT strategies in primary healthcare proposed by regulatory bodies and scientific societies and their potential effects on healthcare resources and CRC prognosis. Finally, we will show information regarding FIT-based surveillance as an alternative to endoscopic surveillance after high-risk polyp resection. To conclude, due to the coronavirus disease 2019 pandemic, FIT-based strategies have become extremely relevant since they enable a reduction of colonoscopy demand and access to the healthcare system by selecting individuals with the highest risk of CRC. |
| Databáze: | OpenAIRE |
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