Prevalence and clinical profile of myocardial crypts in hypertrophic cardiomyopathy
| Autor: | Jana Lindberg, John R. Lesser, Ethan J. Rowin, Raymond H. Chan, James E. Udelson, David Lin, Martin S. Maron, Barry J. Maron, Evan Appelbaum, C. Michael Gibson, Warren J. Manning, Tammy S. Haas |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Gadolinium DTPA Male medicine.medical_specialty Pathology Adolescent Genotype Minnesota Contrast Media Magnetic Resonance Imaging Cine Muscle hypertrophy Basal (phylogenetics) Electrocardiography Internal medicine medicine Prevalence Humans Radiology Nuclear Medicine and imaging cardiovascular diseases Prospective Studies Prospective cohort study Child medicine.diagnostic_test business.industry Case-control study Hypertrophic cardiomyopathy Reproducibility of Results Magnetic resonance imaging Middle Aged medicine.disease Echocardiography Doppler medicine.anatomical_structure Phenotype Ventricle Case-Control Studies cardiovascular system Cardiology Female Hypertrophy Left Ventricular Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. Cardiovascular imaging. 5(4) |
| ISSN: | 1942-0080 |
| Popis: | Background— In hypertrophic cardiomyopathy (HCM), cardiovascular MR can detect morphological abnormalities of the left ventricle (LV) not visualized with echocardiography. Although myocardial crypts (ie, narrow, blood-filled invaginations within the LV wall) have been recognized in HCM, all clinical implications of these structural abnormalities within the broad clinical HCM spectrum are not completely resolved. Therefore, we sought to characterize the prevalence and diagnostic significance of myocardial crypts in HCM patients. Methods and Results— Cine and late gadolinium enhancement cardiovascular MR and 2-dimensional echocardiography were obtained in 292 consecutive patients with HCM including 31 genotype-positive/phenotype-negative family members without LV hypertrophy (28 ± 16 years; 51% male) and 261 patients with LV hypertrophy (46 ± 18 years; 60% male). Ninety-eight subjects without cardiovascular disease were controls. Myocardial crypts (1–6/patient) were identified only by cardiovascular MR in 19 of 31 genotype-positive/phenotype-negative patients (61%) compared with only 10 of 261 (4%) patients with HCM with LV hypertrophy ( P Conclusions— LV myocardial crypts represent a distinctive morphological expression of HCM, occurring with different frequency in HCM patients with or without LV hypertrophy. Crypts are a novel cardiovascular MR imaging marker, which may identify individual HCM family members who should also be considered for diagnostic genetic testing. These data support an expanded role for cardiovascular MR in early evaluation of HCM families. |
| Databáze: | OpenAIRE |
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