Two new antifungal saponins from the Tibetan herbal medicine Clematis tangutica
| Autor: | Na Ze-Ren-Wang-Mu, Yuemao Shen, Zhi-Zhi Du, Na Zhu |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Clematis
Antifungal Agents Stereochemistry Trichosporon beigelii Saponin Pharmaceutical Science Candida glabrata Microbial Sensitivity Tests Saccharomyces cerevisiae Tibet Analytical Chemistry chemistry.chemical_compound Triterpene Trichosporon Amphotericin B Drug Discovery medicine Humans Pharmacology chemistry.chemical_classification biology Traditional medicine Plant Extracts Organic Chemistry Fungi Penicillium Plant Components Aerial Saponins biology.organism_classification Hederagenin Complementary and alternative medicine chemistry Molecular Medicine Medicine Traditional medicine.drug Phytotherapy |
| Zdroj: | Planta medica. 69(6) |
| ISSN: | 0032-0943 |
| Popis: | Bioassay-guided fractionation of the ethanol extract of the aerial parts of Clematis tangutica led to the isolation of two new antifungal triterpene saponins. Their structures were determined to be 3- O-alpha- L-arabinopyranosyl hederagenin 28- O-alpha- L-rhamnopyranosyl ester ( 1) and 3- O-beta- D-glucopyranosyl-(1--4)-alpha- L-arabinopyranosyl hederagenin 28- O-alpha- L-rhamnopyranosyl ester ( 2) on the basis of spectral data and chemical evidence. Inhibitory activities of the two saponins against seven fungal strains were evaluated. Compounds 1 and 2 showed evident antifungal activity (MIA approximately 2.5 micrograms/disc) against Saccharomyces cerevisiae, similar to the positive control amphotericin B and ordinary activities (MIA approximately 10 micrograms/disc) against Penicillium avellaneum UC-4376, Candida glabrata, Trichosporon beigelii and Pyricularia oryzae. Compound 2 is a better antifungal agent than compound 1 against most of the fungal strains that were tested. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|