Trends in COVID-19 hospital outcomes in England before and after vaccine introduction, a cohort study
| Autor: | Peter D. Kirwan, Andre Charlett, Paul Birrell, Suzanne Elgohari, Russell Hope, Sema Mandal, Daniela De Angelis, Anne M. Presanis |
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| Přispěvatelé: | Kirwan, Peter [0000-0001-6904-0500], Apollo - University of Cambridge Repository, Kirwan, Peter D [0000-0001-6904-0500], Birrell, Paul [0000-0001-8131-4893] |
| Rok vydání: | 2022 |
| Předmět: |
FOS: Computer and information sciences
141 Vaccines 692/700/478 Multidisciplinary SARS-CoV-2 article General Physics and Astronomy COVID-19 General Chemistry Statistics - Applications General Biochemistry Genetics and Molecular Biology Hospitals Cohort Studies Humans Applications (stat.AP) 692/699/255 692/308/174 631/326/596/4130 |
| DOI: | 10.17863/cam.87650 |
| Popis: | Widespread vaccination campaigns have changed the landscape for COVID-19, vastly altering symptoms and reducing morbidity and mortality. We estimate trends in mortality by month of admission and vaccination status among those hospitalised with COVID-19 in England between March 2020 to September 2021, controlling for demographic factors and hospital load. Among 259,727 hospitalised COVID-19 cases, 51,948 (20.0%) experienced mortality in hospital. Hospitalised fatality risk ranged from 40.3% (95% confidence interval 39.4-41.3%) in March 2020 to 8.1% (7.2-9.0%) in June 2021. Older individuals and those with multiple co-morbidities were more likely to die or else experienced longer stays prior to discharge. Compared to unvaccinated people, the hazard of hospitalised mortality was 0.71 (0.67-0.77) with a first vaccine dose, and 0.56 (0.52-0.61) with a second vaccine dose. Compared to hospital load at 0-20% of the busiest week, the hazard of hospitalised mortality during periods of peak load (90-100%), was 1.23 (1.12-1.34). The prognosis for people hospitalised with COVID-19 in England has varied substantially throughout the pandemic and according to case-mix, vaccination, and hospital load. Our estimates provide an indication for demands on hospital resources, and the relationship between hospital burden and outcomes. This research is funded by the Medical Research Council (Unit programme number MC_UU_00002/11); a grant from the MRC UKRI/DHSC NIHR COVID-19 rapid response call (grant ref: MC_PC_19074); and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation. This research is also funded by the Department of Health and Social Care using UK Aid funding, managed by the NIHR (grant number PR-OD-1017-20006) |
| Databáze: | OpenAIRE |
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