Evaluation of kidney function in renal transplant patients receiving long-term cyclosporine
| Autor: | Gabriel M. Danovitch, Randall A. Hawkins, Larry A. Slomowitz, Alan H. Wilkinson |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Urology Renal function Cyclosporins Kidney Function Tests Excretion chemistry.chemical_compound Internal medicine medicine Albuminuria Humans Prospective Studies Kidney transplantation Dialysis Body surface area Creatinine medicine.diagnostic_test business.industry Radioisotope renography Organotechnetium Compounds Pentetic Acid medicine.disease Kidney Transplantation Endocrinology chemistry Nephrology Technetium Tc 99m Pentetate Microalbuminuria business Radioisotope Renography |
| Zdroj: | American journal of kidney diseases : the official journal of the National Kidney Foundation. 15(6) |
| ISSN: | 0272-6386 |
| Popis: | We prospectively assessed renal function in a group of 29 renal transplant patients receiving cyclosporine (CsA) in order to determine the course of their renal function over time and the relationship between different markers of glomerular function. We measured serum creatinine, DPTA, and creatinine clearances, and urinary albumin excretion. The clinical course of 24 patients (83%) permitted repeat studies over a period of 32 +/- 1 (SEM) months, and in these patients DTPA clearance, creatinine clearance, and the serum creatinine concentration did not vary with time. Five of the patients (17%) lost their grafts and returned to dialysis. On initial evaluation patients who lost their grafts had a lower DPTA clearance than those whose function was maintained (29 +/- 3 v 46 +/- 2 mL/min/1.73 m2 body surface area [BSA], respectively, P less than 0.005) and all of them had a DTPA clearance of less than 40 mL/min/1.73 m2 BSA. There was an inverse correlation between the log of the urinary albumin excretion and the DTPA clearance (n = 33, r = -0.59, P less than 0.001), a direct correlation with the serum creatinine concentration (N = 33, r = 0.89, P less than 0.0001), but no correlation with time after transplantation. Thus, despite the continued use of CsA, renal function over time was stable in patients who underwent repeated studies, as was the relationship between the DTPA clearance and the clinically used markers of transplant function, the serum creatinine concentration, and the creatinine clearance. |
| Databáze: | OpenAIRE |
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