Comparative experiments on the urinary excretion of exogenous oxytocin and vasopressin
| Autor: | Per Frandsen, Aage Theil Nielsen, Svend Erik Jensen |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Male
medicine.medical_specialty Vasopressin business.industry Vasopressins Endocrinology Diabetes and Metabolism Inulin General Medicine Water-Electrolyte Balance Oxytocin Endocrinology Urinary excretion Internal medicine medicine Animals Rabbits business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Acta endocrinologica. 73(4) |
| ISSN: | 0001-5598 |
| Popis: | The urinary excretion of oxytocin (milk-ejecting activity) and arginine vasopressin (antidiuretic activity) in water-loaded rabbits was measured following simultaneous intravenous injection of 1–9 IU of oxytocin and 0.1–0.3 IU of vasopressin per animal. The percentage excretion of vasopressin was 2–10 times that of oxytocin. Experiments with a steady state blood level of vasopressin and oxytocin maintained by continuous infusion showed, that the vasopressin/oxytocin ratio increased 2–6 times, when the hormones passed from the blood into the urine. This indicates a difference in the renal handling of the hormones with regard to the mechanism of the urinary excretion. The urinary clearance of vasopressin was about the same as that of inulin, consistent with the hypothesis, that vasopressin is excreted mainly by glomerular filtration. The clearance of oxytocin was lower than that of vasopressin and inulin, indicating that oxytocin is filtered at a lower rate (binding to plasma proteins) or partly re-absorbed or inactivated in the tubules and/or collecting ducts. |
| Databáze: | OpenAIRE |
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