A spectrum of exercise training reduces soluble Aβ in a dose-dependent manner in a mouse model of Alzheimer's disease
| Autor: | Jessica L. Restivo, Renee E. Girens, Maria R. Jones, Scott D. Zimmerman, Sara K. Larson, David M. Holtzman, John R. Cirrito, Kaitlin M. Moore, Carla M. Yuede, Benjamin F. Timson |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Hippocampus Random Allocation 0302 clinical medicine Citrate synthase Heat shock protein 70 Treadmill Neprilysin computer.programming_language Cerebral Cortex biology sed Alzheimer's disease Exercise Therapy Up-Regulation Treatment Outcome medicine.anatomical_structure Matrix Metalloproteinase 9 Neurology Cerebral cortex Low Density Lipoprotein Receptor-Related Protein-1 medicine.medical_specialty Mice Transgenic Citrate (si)-Synthase Motor Activity lcsh:RC321-571 Exercise training 03 medical and health sciences Alzheimer Disease Internal medicine medicine Amyloid-β clearance proteins Animals HSP70 Heat-Shock Proteins Amyloid-β RNA Messenger Muscle Skeletal lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Soleus muscle Amyloid beta-Peptides Physical activity Tumor Suppressor Proteins Training effect Peptide Fragments Disease Models Animal 030104 developmental biology Endocrinology Receptors LDL biology.protein computer 030217 neurology & neurosurgery |
| Zdroj: | Neurobiology of Disease, Vol 85, Iss, Pp 218-224 (2016) |
| Popis: | Physical activity has long been hypothesized to influence the risk and pathology of Alzheimer's disease. However, the amount of physical activity necessary for these benefits is unclear. We examined the effects of three months of low and high intensity exercise training on soluble Aβ40 and Aβ42 levels in extracellular enriched fractions from the cortex and hippocampus of young Tg2576 mice. Low (LOW) and high (HI) intensity exercise training animals ran at speeds of 15 m/min on a level treadmill and 32 m/min at a 10% grade, respectively for 60 min per day, five days per week, from three to six months of age. Sedentary mice (SED) were placed on a level, non-moving, treadmill for the same duration. Soleus muscle citrate synthase activity increased by 39% in the LOW group relative to SED, and by 71% in the HI group relative to LOW, indicating an exercise training effect in these mice. Soluble Aβ40 concentrations decreased significantly in an exercise training dose-dependent manner in the cortex. In the hippocampus, concentrations were decreased significantly in the HI group relative to LOW and SED. Soluble Aβ42 levels also decreased significantly in an exercise training dose-dependent manner in both the cortex and hippocampus. Five proteins involved in Aβ clearance (neprilysin, IDE, MMP9, LRP1 and HSP70) were elevated by exercise training with its intensity playing a role in each case. Our data demonstrate that exercise training reduces extracellular soluble Aβ in the brains of Tg2576 mice in a dose-dependent manner through an up-regulation of Aβ clearance. |
| Databáze: | OpenAIRE |
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