Dosing strategies to optimize currently available anti-MRSA treatment options (Part 1: IV options)
| Autor: | Shibin Varghese, Ronald G. Hall nd, Lincy Varughese, Michael Thatcher, Michelle Ndiulor, Wei Wei, Kenna D. Payne |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Methicillin-Resistant Staphylococcus aureus medicine.medical_specialty Individualized dosing 030106 microbiology Microbial Sensitivity Tests Anti mrsa 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Drug Resistance Bacterial medicine Animals Humans Pharmacology (medical) 030212 general & internal medicine Dosing General Pharmacology Toxicology and Pharmaceutics Intensive care medicine medicine.diagnostic_test Dose-Response Relationship Drug business.industry Treatment options General Medicine Staphylococcal Infections Antimicrobial Surgery Anti-Bacterial Agents Dose optimization Therapeutic drug monitoring Administration Intravenous Drug Monitoring business |
| Zdroj: | Expert review of clinical pharmacology. 10(5) |
| ISSN: | 1751-2441 |
| Popis: | Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) continues to be a predominant pathogen resulting in significant morbidity and mortality. Optimal dosing of anti-MRSA agents is needed to help prevent the development of antimicrobial resistance and to increase the likelihood of a favorable clinical outcome.Areas covered: This review summarizes the available data for antimicrobials routinely used for MRSA infections that are not administered orally or topically. We make recommendations and highlight the current gaps in the literature. A PubMed (1966 – Present) search was performed to identify relevant literature for this review.Expert commentary: Improvements in MIC determination and therapeutic drug monitoring are needed to fully implement individualized dosing that optimizes antimicrobial pharmacodynamics.Additional data will become available for these agents in regards to effectiveness for severe MRSA infections and pharmacokinetic data for special patient populations. |
| Databáze: | OpenAIRE |
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