Photocrosslinkable polysaccharides forin situ hydrogel formation
| Autor: | Kourosh Dastgheib, Makoto Inoue, Mark W. Grinstaff, Kimberly A. Smeds, Anne Pfister-Serres, Daijiro Miki, Diane L. Hatchell |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Materials science
Aqueous solution technology industry and agriculture Biomedical Engineering macromolecular substances Methacrylate complex mixtures Viscoelasticity Biomaterials Polymerization Tissue engineering Self-healing hydrogels medicine Swelling medicine.symptom In situ polymerization Composite material |
| Zdroj: | Journal of Biomedical Materials Research. 54:115-121 |
| ISSN: | 1097-4636 0021-9304 |
| Popis: | In situ photopolymerization is an exciting new technique for tissue engineering. Two photocrosslinkable polysaccharides composed of alginate and hyaluronan are described that upon photolysis form soft, flexible, and viscoelastic hydrogels. The degree of methacrylate modification and thus covalent affects mechanical properties such as swelling, compression, and creep compliance. Significant swelling is observed in aqueous solution; these hydrogels can swell up to 14 times their dry weight. Both hydrogels exhibit low phase angles and (G*) values indicative of viscoelastic materials. The hyaluronan based hydrogel is stronger and more resilient than the corresponding alginate gel. SEM and AFM studies on both hydrogels show smooth and uniform surfaces at the macroscopic level with salient features observed only on the nanometer scale. Rapid polymerization by an optical trigger allows for controlled in situ photopolymerization in a minimally invasive manner, indicating that these hydrogels are relevant for biomedical applications such as sealing wounds and reconstructing soft tissues. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text