FoxO3a mediates glioma cell invasion by regulating MMP9 expression
| Autor: | Sufang Dong, Rui-Jia Fu, Huamin Wang, Hua Pei, Ke Xu, Wen-Ming Wang, Zhenhao Zhang |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research Cell Matrix metalloproteinase MMP9 Biology 03 medical and health sciences Cell Movement Glioma Cell Line Tumor medicine Gene silencing Humans Neoplasm Invasiveness Neoplasm Metastasis Regulation of gene expression Forkhead Box Protein O3 General Medicine Cell cycle medicine.disease Cell biology Gene Expression Regulation Neoplastic 030104 developmental biology medicine.anatomical_structure Oncology Matrix Metalloproteinase 9 Ectopic expression |
| Zdroj: | Oncology reports. 36(5) |
| ISSN: | 1791-2431 |
| Popis: | The role of FoxO3a in glioma progression is poorly defined. Herein, we show that silencing FoxO3a in U251 cells leads to decreased invasive migration and proliferation, while ectopic expression of FoxO3a in U87 cells with weak endogenous FoxO3a protein levels enhances invasion and proliferation. To further investigate the mechanism by which FoxO3a promotes invasion, we detected key members of the matrix metalloproteinases (MMPs) that are associated with invasion. Our findings showed that, among these MMP members, only FoxO3a induced MMP9 expression, and MMP9 overexpression reversed the effect that silencing FoxO3a had on the attenuation of cell invasion. Taken together, these data link FoxO3a to the promotion of metastasis in glioma cells. |
| Databáze: | OpenAIRE |
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