Alterations in the Profile of Blood Cell Types during Malaria in Previously Unexposed Primigravid Monkeys
| Autor: | Linda B. Rogers, Michael C. Henson, Sonia Montenegro, Kelsi K. Rasmussen, Donald J. Krogstad, Elizabeth W. Henson, Billie B. Davison, Terri Rasmussen, Fawaz Mzwaek, M. Bernice Kaack |
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| Rok vydání: | 2005 |
| Předmět: |
Anemia
Lymphocyte Parasitemia Biology Immune system Pregnancy T-Lymphocyte Subsets parasitic diseases medicine Animals Immunology and Allergy Plasmodium coatneyi Fetus Pregnancy Complications Hematologic medicine.disease Macaca mulatta Blood Cell Count Malaria Infectious Diseases medicine.anatomical_structure Pregnancy Complications Parasitic Immunology Female |
| Zdroj: | The Journal of Infectious Diseases. 191:1940-1952 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/430004 |
| Popis: | Malaria in nonimmune, primigravid women threatens both mother and fetus. We used the Plasmodium coatneyi/rhesus monkey model to examine factors associated with this. Clinical and immunologic responses during the blood stage of chronic malaria (4 months) were evaluated in 8 malaria-naive primigravid (PMI) and 8 age-matched nulligravid (NMI) infected monkeys, compared with those in 8 primigravid, noninfected control monkeys. Although parasitemia levels were similar, recrudescence was more frequent and prolonged, and anemia was more severe in PMI than in NMI monkeys. During infection, CD2+, CD4+, and CD8+ lymphocyte levels were higher in NMI than in PMI monkeys. Monocyte and neutrophil levels were lower in PMI than in NMI monkeys. During chronic, untreated malaria, NMI monkeys had a B lymphocyte count 23 times greater than that of PMI monkeys. Pregnancy-induced immunomodulation, defined as a lack of appropriate cellular responses to malaria, was indiscernible until the immune system was challenged by a pathogen. |
| Databáze: | OpenAIRE |
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