Intellectual outcome in children and adolescents with acute lymphoblastic leukaemia treated with chemotherapy alone: age- and sex-related differences
| Autor: | U. Caflisch, F Niggli, Wagner Hp, Andreas Hirt, Pierre Wacker, M Nenadov Beck, P. Imbach, Feldges A, I Mosimann, N von der Weid |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Cancer Research Pediatrics medicine.medical_specialty Adolescent Cross-sectional study medicine.medical_treatment Intelligence Neuropsychological Tests Intelligence/drug effects Sex Factors Acute lymphocytic leukemia Antineoplastic Combined Chemotherapy Protocols medicine Humans Survivors Child Survivors/psychology Intelligence Tests Analysis of Variance Chemotherapy ddc:618 Intelligence quotient business.industry Antineoplastic Combined Chemotherapy Protocols/adverse effects Neuropsychology Infant Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Institutional repository Cross-Sectional Studies Oncology El Niño Child Preschool Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/psychology Female business Cohort study |
| Zdroj: | European Journal of Cancer, Vol. 39, No 3 (2003) pp. 359-65 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/s0959-8049(02)00260-5 |
| Popis: | One of the most relevant concerns in long-term survivors of paediatric acute lymphoblastic leukaemia (ALL) is the development of neuropsychological sequelae. The majority of the published studies report on patients treated with chemotherapy and prophylactic central nervous system (CNS) irradiation, little is known about the outcome of patients treated with chemotherapy-only regimens. Using the standardised clinical and neuropsychological instruments of the SPOG Late Effects Study, the intellectual performance of 132 paediatric ALL patients treated with chemotherapy only was compared to that of 100 control patients surviving from diverse non-CNS solid tumours. As a group, ALL and solid tumour survivors showed normal and comparable intellectual performances (mean global IQ 104.6 in both groups). The percentage of patients in the borderline range (global IQ between 70 and 85) was comparable and not higher as expected (10% cases and 13% controls, expected 16%). Only 2 (2%) of the former ALL and 1 (1%) of the solid tumour patients were in the range of mental retardation (global IQ |
| Databáze: | OpenAIRE |
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