Tumor-associated macrophage-derived CCL5 promotes chemotherapy resistance and metastasis in prostatic cancer
| Autor: | Jian Ma, Peng Chen, Rong Zhang, Jing Ma, Meng Wei, Tingting Hua, Junyan Su, Fuerhaiti Shayiti |
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| Rok vydání: | 2021 |
| Předmět: |
Homeobox protein NANOG
Male STAT3 Transcription Factor Lung Neoplasms Antineoplastic Agents Apoptosis Tumor-associated macrophage Mice SCID Metastasis Mice stomatognathic system Mice Inbred NOD Tumor-Associated Macrophages medicine Tumor Cells Cultured Animals Humans STAT3 Chemokine CCL5 Cell Proliferation Tumor microenvironment biology business.industry Cancer Prostatic Neoplasms Cell Biology General Medicine medicine.disease Xenograft Model Antitumor Assays Gene Expression Regulation Neoplastic Tumor progression Drug Resistance Neoplasm Cancer cell Cancer research biology.protein business |
| Zdroj: | Cell biology internationalREFERENCES. 45(10) |
| ISSN: | 1095-8355 |
| Popis: | The crosstalk between tumor microenvironment and cancer cells is emerging as a critical determinant in tumor progression. However, the underlying mechanism of tumor microenvironment-induced cancer development remains controversial. Here, our study provides evidence to suggest that tumor-associated macrophage (TAM) enrichment is found in chemo-resistant prostatic tumor tissues. Those TAMs are demonstrated to promote chemo-resistance and distant metastasis in prostatic cancer through secretion of CCL5. Mechanistically, TAM co-culture or additional CCL5 can mediate the STAT3-dependent epithelial-mesenchymal transition (EMT) process, resulting in distant metastasis in prostatic cancer. Meanwhile, activation of STAT3 induced by CCL5 can mediate up-regulation of the transcription factor Nanog, leading to drug resistance. In vivo study further demonstrated that blockade of STAT3 signals significantly reverses chemo-resistance and suppresses lung metastasis in colorectal tumor-bearing mice, suggesting a novel strategy for clinical prostatic cancer treatment. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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