Distinctive Tissue and Serum MicroRNA Profile of IgG4-Related Ophthalmic Disease and MALT Lymphoma

Autor:	Hiroshi Goto, Kazuhiko Umazume, Kinya Tsubota, Masaki Asakage, Masakatsu Takanashi, Hiroyuki Shimizu, Naoya Nezu, Shin-ichiro Ohno, Akitomo Narimatsu, Naoyuki Yamakawa, Masahiko Kuroda, Yoshihiko Usui
Rok vydání:	2020
Předmět:	0301 basic medicine genetic structures lcsh:Medicine Lymphoproliferative disorders medicine.disease_cause Article Pathogenesis 03 medical and health sciences 0302 clinical medicine immune system diseases hemic and lymphatic diseases microRNA Biopsy medicine IgG4-related disease IgG4-related ophthalmic disease medicine.diagnostic_test business.industry orbital lymphoproliferative disorders lcsh:R orbital MALT lymphoma machine-learning MALT lymphoma General Medicine medicine.disease eye diseases Lymphoma 030104 developmental biology Lymphatic system 030220 oncology & carcinogenesis Cancer research sense organs Carcinogenesis business
Zdroj:	Journal of Clinical Medicine Volume 9 Issue 8 Journal of Clinical Medicine, Vol 9, Iss 2530, p 2530 (2020)
ISSN:	2077-0383
DOI:	10.3390/jcm9082530
Popis:	The molecular pathogenesis of orbital lymphoproliferative disorders, such as immunoglobulin G4-related ophthalmic disease (IgG4-ROD) and orbital mucosa-associated lymphoid tissue (MALT) lymphoma, remains essentially unknown. Differentiation between the two disorders, which is important since the work-up and treatment can vary greatly, is often challenging due to the lack of specific biomarkers. Although miRNAs play an important role in the regulation of carcinogenesis and inflammation, the relationship between miRNA and orbital lymphoproliferative diseases remains unknown. We performed a comprehensive analysis of 2565 miRNAs from biopsy and serum specimens of 17 cases with IgG4-ROD, where 21 cases with orbital MALT lymphoma were performed. We identified specific miRNA signatures and their miRNA target pathways, as well as the network analysis for IgG4-ROD and orbital MALT lymphoma. Machine-learning analysis identified miR-202-3p and miR-7112-3p as the best discriminators of IgG4-ROD and orbital MALT lymphoma, respectively. Enrichment analyses of biological pathways showed that the longevity-regulating pathway in IgG4-ROD and the mitogen-activated protein kinase (MAPK) signaling pathway in orbital MALT lymphoma was most enriched by target genes of downregulated miRNAs. This is the first evidence of miRNA profiles of biopsy and serum specimens of patients with IgG4-ROD and orbital MALT lymphoma. These data will be useful for developing diagnostic and therapeutic interventions, as well as elucidating the pathogenesis of these disorders.
Databáze:	OpenAIRE
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