Parcellation-based modeling of the supplementary motor area
| Autor: | Robert G. Briggs, Isabella M. Young, Chad A. Glenn, Michael Y. Bai, Cordell M Baker, Christen M. O'Neal, Michael E. Sughrue, Andrew K. Conner, Yueh-Hsin Lin, John R. Sheets, Anujan Poologaindran |
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| Rok vydání: | 2021 |
| Předmět: |
Computer science
Gyrus Cinguli Lateralization of brain function 03 medical and health sciences 0302 clinical medicine Neural Pathways Connectome medicine Humans 030212 general & internal medicine Cued speech Brain Mapping Human Connectome Project Supplementary motor area Motor Cortex Hand SMA Magnetic Resonance Imaging medicine.anatomical_structure Neurology Neurology (clinical) Primary motor cortex Insula Neuroscience 030217 neurology & neurosurgery Tractography |
| Zdroj: | Journal of the Neurological Sciences. 421:117322 |
| ISSN: | 0022-510X |
| Popis: | Introduction The supplementary motor area (SMA) plays an important role in the initiation and coordination of internally and externally cued movements. Such movements include reaching, grasping, speaking, and bilateral hand coordination. While many studies discuss the SMA and its relationship to other parts of the motor network, there is minimal literature examining the connectivity of the SMA outside of the motor network. Using region-based fMRI studies, we built a neuroanatomical model to account for these extra-motor connections. Methods Thirty region-based fMRI studies were used to generate an activation likelihood estimation (ALE) using BrainMap software. Cortical parcellations overlapping the ALE were used to construct a preliminary model of the SMA connections outside the motor network. DSI-based fiber tractography was performed to determine the connectivity between cortical parcellations. The resulting connections were described using the cortical parcellation scheme developed by the Human Connectome Project (HCP). Results Four left hemisphere regions were found to comprise the SMA. These included areas SFL, SCEF, 6ma, and 6mp. Across mapped brains, these areas showed consistent interconnections between each other. Additionally, ipsilateral connections to the primary motor cortex, left inferior and middle frontal gyri, the anterior cingulate gyrus, and insula were demonstrated. Connections to the contralateral SMA, anterior cingulate, lateral premotor, and inferior frontal cortices were also identified. Conclusions We describe a preliminary cortical model for the underlying structural connectivity of the supplementary motor area outside the motor network. Future studies should further characterize the neuroanatomic underpinnings of this network for the purposes of medical application. |
| Databáze: | OpenAIRE |
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