Early dynamic 18F-FDG PET/CT to diagnose chronic osteomyelitis following lower extremity fractures
| Autor: | F. F. Stecker, D. Driesch, J.-H. Schierz, T. Opfermann, T. Winkens, M. Freesmeyer, Gunther O. Hofmann |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Pilot Projects Bone healing Multimodal Imaging Sensitivity and Specificity 030218 nuclear medicine & medical imaging Fractures Bone 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Humans Medicine Radiology Nuclear Medicine and imaging In patient business.industry Reproducibility of Results Osteomyelitis General Medicine Middle Aged Bone area Image Enhancement List mode Surgery Early Diagnosis Positron-Emission Tomography 030220 oncology & carcinogenesis Female Radiopharmaceuticals Tomography X-Ray Computed business Nuclear medicine Leg Injuries |
| Zdroj: | Nuklearmedizin. 53:117-122 |
| ISSN: | 2567-6407 0029-5566 |
| DOI: | 10.3413/nukmed-0572-13-03 |
| Popis: | SummaryAim: The study investigates whether early dynamic PET/CT (edPET/CT) using 18F-fluoro- deoxyglucose (FDG) discriminates between affected versus non-affected sites in patients with complicated, protracted fracture healing and suspected COM in the lower extremities. Patients, methods: In nine consecutive patients (1 woman, 8 men; age 54 ± 13 years), before standard late FDG-PET/CT, altogether 10 edFDG-PET/CT examinations were performed in list mode over 5 min starting with radiopharmaceutical injection. Eight consecutive time intervals (frames), four 15-s, then four 60-s, were reconstructed. For every patient, several volumes-of-interest were selected. To measure early FDG influx and accumulation, maximum and mean ed standardized uptake values (respectively, ed SUVmax, edSUVmean) were calculated in each volume-of-interest during each frame. Results were compared between affected and non-affected (contralateral) bone. Results: Starting in the 31-45s frame, the affected bone area showed significantly higher ed- SUVmax and edSUVmean than did the healthy contralateral region. In conventional PET/CT, affected bone areas also significantly differed from non-affected contralateral regions. Conclusion: This pilot study suggests that edFDG- PET may offer a less time consuming add on to standard FDG-PET/CT while being equally accurate. The results should be validated pros- pectively in larger trials. |
| Databáze: | OpenAIRE |
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