Corneal Dendritic Cell Density Is Associated with Subbasal Nerve Plexus Features, Ocular Surface Disease Index, and Serum Vitamin D in Evaporative Dry Eye Disease
| Autor: | Swaminathan Sethu, Rushad Shroff, Aarti Agrawal, Kalyani Deshpande, Rashmi Deshmukh, Arkasubhra Ghosh, Rohit Shetty |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Article Subject lcsh:Medicine Pain Dry Eye Syndromes Cell Count Disease General Biochemistry Genetics and Molecular Biology Cornea 03 medical and health sciences Nerve Fibers 0302 clinical medicine Ophthalmology medicine Vitamin D and neurology Humans Ocular Surface Disease Index Vitamin D Aged Serum vitamin General Immunology and Microbiology business.industry lcsh:R Nerve plexus Dendritic Cells General Medicine Dendritic cell Middle Aged Healthy Volunteers medicine.anatomical_structure 030221 ophthalmology & optometry Female business 030217 neurology & neurosurgery Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2016 (2016) |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2016/4369750 |
| Popis: | Dry eye disease (DED) has evolved into a major public health concern with ocular discomfort and pain being responsible for significant morbidity associated with DED. However, the etiopathological factors contributing to ocular pain associated with DED are not well understood. The current IVCM based study investigated the association between corneal dendritic cell density (DCD), corneal subbasal nerve plexus (SBNP) features, and serum vitamin D and symptoms of evaporative dry eye (EDE). The study included age and sex matched 52 EDE patients and 43 heathy controls. A significant increase in the OSDI scores (discomfort subscale) was observed between EDE (median, 20.8) and control (median, 4.2) cohorts(P<0.001). Similarly, an increase in DCD was observed between EDE (median, 48.1 cells/mm2) patients and controls (median, 5.6 cells/mm2)(P<0.001). A significant decrease in SBNP features (corneal nerve fiber length, fiber density, fiber width, total branch density, nerve branch density, and fiber area) was observed in EDE patients with OSDI score >23(P<0.05). A positive correlation was observed between DCD and OSDI discomfort subscale (r=0.348;P<0.0003) and SBNP features. An inverse correlation was observed between vitamin D and OSDI scores (r=-0.332;P=0.0095) and DCD with dendritic processes (r=-0.322;P=0.0122). The findings implicate DCD, SBNP features, and vitamin D with EDE symptoms. |
| Databáze: | OpenAIRE |
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