Increased Insulin Receptor Binding to Monocytes from Insulu-dependent Diabetic Patients After a Low-Fat, High-Starch, High-Fiber Diet
| Autor: | Hjøllund E, Oluf Pedersen, Helms P, H O Lindskov, Sørensen Ns, J Ditzel |
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| Rok vydání: | 1982 |
| Předmět: |
Adult
Blood Glucose Dietary Fiber Male medicine.medical_specialty Erythrocytes Starch Endocrinology Diabetes and Metabolism medicine.medical_treatment High fiber diet Monocytes chemistry.chemical_compound Internal medicine Diabetes mellitus Diabetes Mellitus Dietary Carbohydrates Internal Medicine medicine Humans Insulin Advanced and Specialized Nursing biology business.industry Diet study medicine.disease Dietary Fats Receptor Insulin Insulin receptor Endocrinology chemistry Insulin receptor binding biology.protein business |
| Zdroj: | Diabetes Care. 5:284-291 |
| ISSN: | 1935-5548 0149-5992 |
| Popis: | To determine if the insulin sparing effect of a low-fat, high-starch, and high-fiber diet might be mediated through changes of cellular insulin receptor binding, we have in a clinically controlled diet study examined insulin receptors on erythrocytes and monocytes from 40 patients with insulin-dependent diabetes meilitus. Twenty diabetic subjects were treated with a weight-maintaining, low-fat, high-starch, and highfiber diet for 4 wk (alternative diet group) while a comparable group of another 20 diabetic subjects was treated with a conventional high-fat, low-carbohydrate diet (control diet group). In the alternative diet group the intake of starch increased by 56% (P < 0.001) with unchanged intake of simple carbohydrates, the intake of indigestible carbohydrates (fibers) increased by 90% (P < 0.001), the intake of saturated fat was reduced by 32% (P < 0.01) with unchanged intake of polyunsaturated fat, and the cholesterol consumption decreased by 39% (P < 0.01). Food intake remained constant in the control diet group. During the first 2 wk after change of diet the patients in the alternative diet group had frequent clinical signs of increased insulin sensitivity (hypoglycemia) demanding significant reductions (about 25%) of insulin requirement (P < 0.005 after week 1 and P < 0.001 after weeks 2-4). In the same group of diabetic subjects insulin binding to monocytes at insulin tracer concentration increased 25% (P < 0.05) after week 2 and 34% (P < 0.01) after week 4. In contrast insulin receptors on erythrocytes were unchanged. Moreover, significant reductions were shown in fasting plasma concentrations of free insulin (P < 0.02 after weeks 3 and 4) and ketone bodies (P < 0.05 after week 3 and P < 0.01 after week 4), and fasting serum concentration of total cholesterol (P < 0.001 after weeks 2 and 4). No significant changes occurred in the alternative diet group in the following quantities: fasting plasma and 24-h urine glucose concentrations, percentage of glycosylated hemoglobin, fasting plasma concentrations of FFA, or fasting serum concentration of triglyceride. No significant changes in any of the measured variables were found in the control diet group. We conclude that the insulin sparing effect of a low-fat, high-starch, high-fiber diet in insulin-dependent diabetic subjects may be partly mediated through an increased insulin binding. Improved metabolic control was obtained as judged by the significant fall of the plasma concentration of ketone bodies while glycemia and glucosuria were unchanged. |
| Databáze: | OpenAIRE |
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