Eccrine Angiomatous Hamartoma: A Clinicopathologic Review of 18 Cases
| Autor: | Andrew T. Patterson, Monique G. Kumar, Patricia M. Witman, Susan J. Bayliss, Alejandro A. Gru, Louis P. Dehner |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Hamartoma Dermatology Eccrine Glands Uncommon disorder Skin Diseases Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences Eccrine gland Young Adult 0302 clinical medicine Dermis medicine Sweat Gland Diseases Humans Child Aged Retrospective Studies Aged 80 and over Eccrine angiomatous hamartoma business.industry Cutaneous lesion Infant Newborn Infant General Medicine Middle Aged medicine.disease Infant newborn medicine.anatomical_structure 030220 oncology & carcinogenesis Child Preschool Female business |
| Zdroj: | The American Journal of dermatopathology. 38(6) |
| ISSN: | 1533-0311 |
| Popis: | Eccrine angiomatous hamartoma (EAH) is a benign cutaneous lesion defined by the proliferation of hamartomatous eccrine and capillary-like vascular elements in the dermis. However, the epidemiologic, morphologic, and histopathologic aspects of this uncommon disorder have yet to be fully delineated.The authors retrospectively reviewed 18 EAH cases (including 14 accompanying skin biopsy specimens) diagnosed at 4 American university hospitals from 1996 to 2014.Patients ranged from 3 days to 84 years at time of diagnosis with a median age of 15 years. A male:female ratio of 11:7 was observed. Sixty-seven percent of cases presented in the extremities, but lesions in the trunk and head/neck regions also occurred. Four patients had multiple lesions, and 2 displayed a segmental pattern. Histologically, dermal vascular dilatation and acanthosis often accompanied EAH's typical eccrine and vascular comingling. One individual developed EAH at the site of a recurrent squamous cell carcinoma after previous excision.Although previously thought to occur primarily as a solitary angiomatous-appearing malformation on the extremities of children, EAH may develop with some frequency in adults and may manifest in a multifocal linear distribution. The authors also raise additional histopathologic consideration in support of the vascular theory of histogenesis for this condition. |
| Databáze: | OpenAIRE |
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