Differences in risk for type 1 and type 2 ovarian cancer in a large cancer screening trial
| Autor: | Hyeong Jun Ahn, Keith Y. Terada, Bruce Kessel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
medicine.medical_specialty endocrine system endocrine system diseases Carcinogenesis medicine.medical_treatment Ibuprofen Contraceptives Oral Hormonal 03 medical and health sciences 0302 clinical medicine Gynecologic Surgical Procedures Risk Factors Pregnancy Internal medicine Salpingectomy Surveys and Questionnaires Cancer screening medicine Humans Early Detection of Cancer Aged Ovarian Neoplasms 030219 obstetrics & reproductive medicine Ectopic pregnancy business.industry Anti-Inflammatory Agents Non-Steroidal Obstetrics and Gynecology Cancer General Medicine Middle Aged medicine.disease female genital diseases and pregnancy complications 3. Good health Pregnancy Ectopic Serous fluid medicine.anatomical_structure 030220 oncology & carcinogenesis Adenocarcinoma Original Article Female Ovarian cancer business Fallopian tube |
| Zdroj: | Journal of Gynecologic Oncology |
| ISSN: | 2005-0399 2005-0380 |
| Popis: | Objective: To investigate the role of previous gynecologic surgery, hormone use, and use of non-steroidal anti-inflammatory drugs on the risk of type 1 and type 2 ovarian cancer. Methods: We utilized data collected for the Prostate, Lung, Colorectal, and Ovarian cancer screening trial. All diagnosed ovarian cancers were divided into three groups: type 1, endometrioid, clear cell, mucinous, low grade serous, and low grade adenocarcinoma/not otherwise specified (NOS); type 2, high grade serous, undifferentiated, carcinosarcoma, and high grade adenocarcinoma/NOS; and other: adenocarcinoma with grade or histology not specified, borderline tumors, granulosa cell tumors. The odds ratios for type 1, type 2, and other ovarian cancers were assessed with regard to historical information for specific risk factors. Results: Ibuprofen use was associated with a decrease in risk for type 1 ovarian cancer. Tubal ligation and oral contraceptive use were associated with a decrease in risk for type 2 ovarian cancer. A history of ectopic pregnancy was associated with a decreased risk for all ovarian cancers by almost 70%. Conclusion: These findings support the hypothesis that carcinogenic pathways for type 1 and type 2 ovarian cancer are different and distinct. The marked reduction in all ovarian cancer risk noted with a history of ectopic pregnancy and salpingectomy implies that the fallopian tube plays a key role in carcinogenesis for both type 1 and type 2 ovarian cancer. |
| Databáze: | OpenAIRE |
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