Clinical Significance of CLDN18.2 Expression in Metastatic Diffuse-Type Gastric Cancer
| Autor: | In-Ho Kim, Jae Myung Park, Seo Ree Kim, Kyo Yong Song, Sang-Yeob Kim, Jeong-Oh Kim, Sung Hak Lee, Bohyun Kim, Kabsoo Shin, Junyoung Seo, Sang-Young Roh, Han Hong Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
medicine.medical_treatment Adherens junction Pathogenesis 03 medical and health sciences 0302 clinical medicine Medicine Chemotherapy Clinical significance Claudin business.industry Cadherin Gastroenterology Bone metastasis Cancer medicine.disease Cadherins Oncology 030220 oncology & carcinogenesis Cancer research 030211 gastroenterology & hepatology Original Article business Gastric cancer |
| Zdroj: | Journal of Gastric Cancer |
| ISSN: | 2093-5641 2093-582X |
| Popis: | Purpose Isoform 2 of tight junction protein claudin-18 (CLDN18.2) is a potential target for gastric cancer treatment. A treatment targeting CLDN18.2 has shown promising results in gastric cancer. We investigated the clinical significance of CLDN18.2 and other cell-adherens junction molecules (Rho GTPase-activating protein [RhoGAP] and E-cadherin) in metastatic diffuse-type gastric cancer (mDGC). Materials and Methods We evaluated CLDN18.2, RhoGAP, and E-cadherin expression using two-plex immunofluorescence and quantitative data analysis of H-scores of 77 consecutive mDGC patients who received first-line platinum-based chemotherapy between March 2015 and February 2017. Results CLDN18.2 and E-cadherin expression was significantly lower in patients with peritoneal metastasis (PM) than those without PM at the time of diagnosis (P=0.010 and 0.013, respectively), whereas it was significantly higher in patients who never developed PM from diagnosis to death than in those who did (P=0.001 and 0.003, respectively). Meanwhile, CLDN18.2 and E-cadherin expression levels were significantly higher in patients with bone metastasis than in those without bone metastasis (P=0.010 and 0.001, respectively). Moreover, we identified a positive correlation between the expression of CLDN18.2 and E-cadherin (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|