Lipoprotein abnormalities in patients with asymptomatic acute porphyria
| Autor: | Rafael Enrı́quez de Salamanca, Teresa Gómez-Izquierdo, Juan Gómez-Gerique, María de la Calle, Amelia Porres, Sagrario Larumbe, Consuelo Fernández-Miranda |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Very low-density lipoprotein medicine.medical_specialty Porphyrins Lipoproteins Cholesterol VLDL Clinical Biochemistry Lipoproteins VLDL Biology Biochemistry Porphyrias chemistry.chemical_compound High-density lipoprotein Reference Values Internal medicine medicine Humans Triglycerides Apolipoproteins B Lipoprotein lipase Apolipoprotein A-I Cholesterol Cholesterol HDL Biochemistry (medical) nutritional and metabolic diseases Lipase General Medicine medicine.disease Lipoprotein Lipase Endocrinology Porphyria Liver chemistry Low-density lipoprotein Acute Disease Female lipids (amino acids peptides and proteins) Hepatic lipase Lipoprotein(a) Lipoprotein |
| Zdroj: | Clinica Chimica Acta. 294:37-43 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/s0009-8981(99)00257-0 |
| Popis: | There have been discrepancies in reports of total cholesterol and low density lipoprotein (LDL)-cholesterol levels in patients with acute porphyria. Some studies have found that acute porphyria patients have increased levels while others do not. The aim of this study has been to evaluate the lipid profile in a series of patients with acute porphyria, in order to help clarify these differences. Serum lipoprotein levels were studied in 30 patients (25 women and five men; age:38+/-10 years) with asymptomatic acute porphyria. Controls were 30 healthy volunteers matched for age and gender. For 13 patients and 15 controls, lipoprotein lipase and hepatic lipase activities were determined. Patients exhibited increased levels of total-cholesterol, LDL-cholesterol, high density lipoprotein (HDL)-cholesterol and apolipoprotein (apo)-A1 compared with controls (P4 mmol/l in 15 patients (50%). Levels of total triglycerides, very low density lipoprotein (VLDL)-triglycerides, VLDL-cholesterol, apo-B and lipoprotein(a) were similar in patients and controls. The hepatic lipase activity tended to be lower in patients than controls (33.8+/-17.7 vs. 50.4+/-23.0 pkat/ml; P=0.05). In conclusion, in patients with asymptomatic acute porphyria an increase of total and LDL-cholesterol was found. The cardiovascular risk conferred by this factor may be attenuated by increased HDL-cholesterol and apo-A1. |
| Databáze: | OpenAIRE |
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