Impact of salivary hypofunction on incidence of orofungal infections with use of topical steroids for management of oral lichen planus and xerostomia
| Autor: | Joel J. Napeñas, Mary Hil Edens, Michael D. Carpenter, Michael T. Brennan |
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| Rok vydání: | 2018 |
| Předmět: |
Antifungal
Male medicine.medical_specialty Antifungal Agents medicine.drug_class medicine.medical_treatment Administration Topical Gastroenterology Normal flow Xerostomia Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) In patient Aged Retrospective Studies business.industry Incidence (epidemiology) Incidence Retrospective cohort study 030206 dentistry Middle Aged medicine.disease stomatognathic diseases Steroid therapy Mycoses 030220 oncology & carcinogenesis Surgery Oral lichen planus Female Steroids Oral Surgery business Mouth Diseases Topical steroid Lichen Planus Oral |
| Zdroj: | Oral surgery, oral medicine, oral pathology and oral radiology. 126(6) |
| ISSN: | 2212-4411 |
| Popis: | Objectives The aim of this study was to determine if salivary hypofunction increases the incidence of oral fungal infections (OFIs) after topical steroid use for the management of oral lichen planus (OLP). Study Design Patients with a diagnosis of OLP, treated for at least 2 weeks with topical steroids, had baseline salivary flow evaluations completed, and had a follow-up visit within 5 weeks of steroids being prescribed were assessed. Patients were evaluated for clinical signs of fungal infection at follow-up visits. Results Forty-Seven patients (91% female) met the inclusion criteria, with 21.3% developing an OFI after topical steroid use. Demographic characteristics, type of OLP, steroid used, and antifungal used did not impact the development of an OFI. The mean stimulated salivary flow was significantly lower in the group that developed an OFI compared with the group that did not develop an OFI (8.31 mL/15 min vs 15.4 mL/15 min, respectively; P = 0.0006). A higher incidence of OFIs occurred in the low stimulated flow group versus the normal flow group (39% vs 4%, respectively). Most patients in the OFI group received a preventative antifungal (90%). Conclusions OFIs increased after steroid treatment in patients with OLP who had low stimulated salivary flows. Antifungals (90%) were not effective in preventing OFIs in patients with OLP who had salivary hypofunction and were treated with topical steroids. |
| Databáze: | OpenAIRE |
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