Binding of heparan sulfate glycosaminoglycan to β-amyloid peptide: inhibition by potentially therapeutic polysulfated compounds

Autor:	A Scanameo, H Fillit, Beatrice Leveugle, W Ding
Rok vydání:	1994
Předmět:	Amyloid biology Chemistry General Neuroscience Heparin Heparan sulfate Pentosan polysulfate carbohydrates (lipids) Glycosaminoglycan chemistry.chemical_compound Sulfation Biochemistry Proteoglycan medicine biology.protein Amyloid precursor protein medicine.drug
Zdroj:	NeuroReport. 5:1389-1392
ISSN:	0959-4965
DOI:	10.1097/00001756-199406270-00024
Popis:	Heparin sulfate proteoglycans are believed to play an important role in amyloidosis as pathologic chaperones. They bind to amyloidogenic proteins and may mediate the deposition and fibrillogenesis of amyloid at specific tissue sites. In the present study, we demonstrate that heparin sulfate glycosaminoglycan and proteoglycan both bind to the beta-amyloid peptide involved in Alzheimer's disease. The interaction of heparan sulfate proteoglycan and glycosaminoglycan can be inhibited by other sulfated compounds such as heparin, dextran sulfate and pentosan polysulfate. These polysaccharides which are currently used clinically, their derivatives or analogs may be effective as therapeutic agents to prevent or slow the progression of amyloidogenesis in Alzheimer's disease or other amyloidogenic disorders.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be9338d513150757e3692fbc6f377d8 https://doi.org/10.1097/00001756-199406270-00024 Zobrazit plný text záznamu