Current Perspectives on 'Off-The-Shelf' Allogeneic NK and CAR-NK Cell Therapies
| Autor: | Mohan C. Vemuri, Tor Espen Stav-Noraas, Shayne Boucher, Navjot Kaur, Andrew D. Hungler, Evan R. Zynda, Erica L. Heipertz |
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| Rok vydání: | 2021 |
| Předmět: |
GMP manufacturing
Induced Pluripotent Stem Cells Immunology Cell Cell- and Tissue-Based Therapy Review CAR-NK cells Immunotherapy Adoptive Neoplasms lentiviral delivery medicine Humans Immunology and Allergy Off the shelf Cell Engineering Receptors Chimeric Antigen natural killer cells business.industry Allogeneic Cells NK cell expansion AAV delivery RC581-607 Fetal Blood Killer Cells Natural killer immune receptors Treatment Outcome medicine.anatomical_structure Cancer research immunotherapy Immunologic diseases. Allergy Current (fluid) business |
| Zdroj: | Frontiers in Immunology, Vol 12 (2021) Frontiers in Immunology |
| ISSN: | 1664-3224 |
| Popis: | Natural killer cells (NK cells) are the first line of the innate immune defense system, primarily located in peripheral circulation and lymphoid tissues. They kill virally infected and malignant cells through a balancing play of inhibitory and stimulatory receptors. In pre-clinical investigational studies, NK cells show promising anti-tumor effects and are used in adoptive transfer of activated and expanded cells, ex-vivo. NK cells express co-stimulatory molecules that are attractive targets for the immunotherapy of cancers. Recent clinical trials are investigating the use of CAR-NK for different cancers to determine the efficiency. Herein, we review NK cell therapy approaches (NK cell preparation from tissue sources, ways of expansion ex-vivo for “off-the-shelf” allogeneic cell-doses for therapies, and how different vector delivery systems are used to engineer NK cells with CARs) for cancer immunotherapy. |
| Databáze: | OpenAIRE |
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