5-(2-Aminopropyl)benzofuran and phenazepam demonstrate the possibility of dependence by increasing dopamine levels in the brain
| Autor: | Jaesuk Yun, Hyung-Soo Kim, Hye Jin Cha, Young-Hoon Kim, Kwang-Wook Lee, Jang-Hyeon Eom, Kyoungmoon Han, Jisoon Shin |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Substance-Related Disorders Dopamine Clinical Biochemistry Self Administration Pharmacology Toxicology Biochemistry Designer Drugs Rats Sprague-Dawley 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound Benzodiazepines Mice 0302 clinical medicine medicine Animals Benzofuran Biological Psychiatry 5-HT receptor 5-APB Benzofurans Mice Inbred ICR Dose-Response Relationship Drug Propylamines Phenazepam Brain Conditioned place preference Rats 030104 developmental biology chemistry NMDA receptor Psychology Self-administration 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 149 |
| ISSN: | 1873-5177 |
| Popis: | Although 5-(2-aminopropyl)benzofuran (5-APB) and 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (phenazepam) are being used as recreational drugs, research on their dependence liability or mechanisms of action is lacking. The present study aimed to evaluate the behavioral effects and dependence liability of these drugs using conditioned place preference and self-administration paradigms in rodents. Additionally, biochemical techniques were used to assess the substance-induced alterations in synaptosome-released dopamine. While both of the tested substances elicited increases in conditioned place preference and dopamine, neither of them facilitated self-administration, suggesting that 5-APB and phenazepam have rewarding effects, rather than reinforcing effects. |
| Databáze: | OpenAIRE |
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