Guinea pig pulmonary mechanics: altered sensitivity to carbachol by cadmium and/or selenium
| Autor: | R. R. Bell, Vani K Nonavinakere, Johnnie L. Early, D. M. Hammerbeck, Magdi R.I. Soliman |
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| Rok vydání: | 1998 |
| Předmět: |
Pulmonary and Respiratory Medicine
Lung Diseases Male medicine.medical_specialty Carbachol medicine.medical_treatment Bronchoconstriction Guinea Pigs chemistry.chemical_element Cadmium chloride Muscarinic Agonists Constriction Guinea pig chemistry.chemical_compound Sodium Selenite Cadmium Chloride Internal medicine medicine Animals Saline Cadmium Pulmonary mechanics Dose-Response Relationship Drug Chemistry Drug Administration Routes Disease Models Animal Drug Combinations Endocrinology Carcinogens Respiratory Mechanics Selenium medicine.drug |
| Zdroj: | Lung. 176(1) |
| ISSN: | 0341-2040 |
| Popis: | Male Hartley guinea pigs (480–610 g) were treated intratracheally as follows: saline, cadmium (Cd, 0.3 mg), selenium (Se, 0.3 or 0.06 mg), or Se (0.06 mg) and Cd (0.3 mg) simultaneously. Selenium and Cd were administered as sodium selenite and cadmium chloride, respectively. Twenty-four h later, dynamic lung compliance (Cdyn) and pulmonary resistance (Rp) were measured before (baseline Cdyn and Rp) and after carbachol administration (0.0001, 0.001, 0.01, and 0.1 μmol/kg, intravenously). Results indicated a significant decrease in baseline Cdyn caused by 0.3 mg of Cd, 0.3 mg or 0.06 mg of Se, and 0.3 mg of Cd with 0.06 mg of Se (p < 0.05). A significant increase in baseline Rp due to 0.3 mg of Se was observed (p < 0.05). Carbachol decreased Cdyn significantly below baseline, evident after lower doses of carbachol, in guinea pigs pretreated with 0.3 mg of Se, whereas a significant improvement in Cdyn was seen after 0.0001 μmol/kg carbachol in the group pretreated with Se and Cd simultaneously (p < 0.05) compared with the respective baseline values of the saline-treated group. Similarly, a significant increase in Rp was observed after carbachol in groups pretreated with 0.3 mg of Cd or Se (p < 0.05). Results also indicated a significant increase in large airway constriction caused by Cd and/or Se (p < 0.05). A leftward shift in the carbachol dose-response curve indicated increased sensitivity to carbachol in Cd- and/or Se-pretreated guinea pigs. |
| Databáze: | OpenAIRE |
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