Hormone replacement therapy, mammographic density, and breast cancer risk: a cohort study

Autor: My von Euler-Chelpin, Anne Tjønneland, Shadi Azam, Elsebeth Lynge, Ilse Vejborg, Stephanie Huynh, Arja R. Aro, Zorana Jovanovic Andersen, Theis Lange
Rok vydání: 2017
Předmět:
Oncology
Cancer Research
medicine.medical_specialty
Hormone Replacement Therapy
medicine.medical_treatment
Hormone Replacement Therapy/adverse effects
Breast Neoplasms
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Breast cancer
Risk Factors
Breast/pathology
Internal medicine
Surveys and Questionnaires
medicine
Humans
030212 general & internal medicine
Breast
skin and connective tissue diseases
Mammographic density
Early Detection of Cancer
Aged
Breast Density
Original Paper
Mammography/methods
business.industry
Hazard ratio
Breast Neoplasms/diagnosis
Cancer
Hormone replacement therapy (menopause)
Middle Aged
medicine.disease
Cancer registry
Diet
Hormone replacement therapy
030220 oncology & carcinogenesis
Relative risk
Cohort
Female
business
Cohort study
Mammography
Breasts density
Zdroj: Cancer Causes & Control
Azam, S, Lange, T, Huynh, S, Aro, A R, von Euler-Chelpin, M, Vejborg, I, Tjønneland, A, Lynge, E & Andersen, Z J 2018, ' Hormone replacement therapy, mammographic density, and breast cancer risk : a cohort study ', Cancer Causes & Control, vol. 29, no. 6, pp. 495-505 . https://doi.org/10.1007/s10552-018-1033-0
Azam, S, Lange, T, Huynh, S, Aro, A R, vpm Eiæer-Chelpin, M, Vejborg, I, Tjønneland, A, Lynge, E & Andersen, Z J 2018, ' Hormone replacement therapy, mammographic density, and breast cancer risk: a cohort study ', Cancer Causes & Control, vol. 29, no. 6, pp. 495–505 . https://doi.org/10.1007/s10552-018-1033-0
ISSN: 1573-7225
DOI: 10.1007/s10552-018-1033-0
Popis: PurposeHormone replacement therapy (HRT) use increases breast cancer risk and mammographic density (MD). We examine whether MD mediates or modifies the association of HRT with the breast cancer.MethodsFor the 4,501 participants in the Danish diet, cancer and health cohort (1993–1997) who attended mammographic screening in Copenhagen (1993–2001), MD (mixed/dense or fatty) was assessed at the first screening after cohort entry. HRT use was assessed by questionnaire and breast cancer diagnoses until 2012 obtained from the Danish cancer registry. The associations of HRT with MD and with breast cancer were analyzed separately using Cox’s regression. Mediation analyses were used to estimate proportion [with 95% confidence intervals (CI)] of an association between HRT and breast cancer mediated by MD.Results2,444 (54.3%) women had mixed/dense breasts, 229 (5.4%) developed breast cancer, and 35.9% were current HRT users at enrollment. Compared to never users, current HRT use was statistically significantly associated with having mixed/dense breasts (relative risk and 95% CI 1.24; 1.14–1.35), and higher risk of breast cancer (hazard ratio 1.87; 1.40–2.48). Association between current HRT use and breast cancer risk was partially mediated by MD (percent mediated = 10%; 95% CI 4–22%). The current HRT use-related breast cancer risk was higher in women with mixed/dense (1.94; 1.37–3.87) than fatty (1.37; 0.80–2.35) breasts (p value for interaction = 0.15).ConclusionsMD partially mediates some of the association between HRT and breast cancer risk. The association between HRT and breast cancer seems to be stronger in women with dense breasts.
Databáze: OpenAIRE
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